Raws li AChE inhibitor, neostigmine reversibly inhibits AChE nyob rau hauv active site los ntawm carbamylation ntawm serine Fig. 4, nyob rau hauv lub mechanism ntawm kev txiav txim. Yog li, nws txhim kho cholinergic kev txiav txim los ntawm kev pab txhawb kev xa mus los ntawm cov neuromuscular junctions.
Acetylcholinesterase inhibited li cas?
Organophosphate (OP) thiab carbamate esters tuaj yeem cuam tshuam acetylcholinesterase (AChE) los ntawm kev khi covalently rau ib qho serine residue nyob rau hauv lub enzyme active site, thiab lawv inhibitory potency nyob ntawm ntau affinity rau enzyme thiab reactivity ntawm ester.
Yuav ua li cas organophosphate inhibit acetylcholinesterase?
Organophosphates yog cov tshuaj tua kab ua liaj ua teb. Cov tshuaj no inhibit enzyme acetylcholinesterase, uas yog lub luag haujlwm rau kev degradation ntawm acetylcholine. Cov organophosphate khi rau cov enzyme, ua rau nws mus rau kev hloov pauv ntawm nws qhov chaw khi rau acetylcholine.
Acetylcholinesterase inhibitors ua haujlwm li cas?
Cholinesterase inhibitors thaiv kev ua ntawm enzyme cholinesterase, uas yog lub luag haujlwm rau kev rhuav tshem acetylcholine. Qhov no nce qib ntawm acetylcholine hauv synaptic cleft (qhov chaw nruab nrab ntawm ob lub paj hlwb).
Dab tsi yog kev ua haujlwm thiab kev ua haujlwm ntawm neostigmine?
Mechanism of Action: Inhibits the hydrolysis ntawm acetylcholine los ntawm kev sib tw nrog acetylcholine rau kev txuas mus rau acetylcholinesterase ntawm qhov chaw ntawm cholinergic kisNws txhim kho cholinergic kev txiav txim los ntawm kev yooj yim rau kev sib kis ntawm impulses hla neuromuscular junctions.
