Sulfonamides sib tw inhibit kev koom ua ke ntawm PABA rau hauv folic acid, yog li tiv thaiv kev sib txuas ntawm folic acid. Trimethoprim khi reversibly rau thiab inhibits dihyrofolate reductase, ib qho enzyme uas txo dihydrofolic acid rau tetrahydrofolic acid, txo folic acid synthesis.
Yuav ua li cas yog lub tswv yim ntawm kev ua ntawm sulfonamides?
Mechanism of Action
Sulfonamides kev sib tw inhibit qhov kev koom ua ke ntawm PABA rau hauv folic acid, yog li tiv thaiv cov synthesis ntawm folic acid Trimethoprim khi reversibly rau thiab inhibits dihyrofolate reductase, ib qho enzyme uas txo cov dihydrofolic acid rau tetrahydrofolic acid, txo folic acid synthesis.
txheej txheem dab tsi ua sulfanilamide inhibit?
Sulfanilamide yog ib qho kev sib tw ntawm cov kab mob enzyme dihydropteroate synthetaseCov enzyme no ib txwm siv para-aminobenzoic acid (PABA) rau kev tsim cov folic acid tsim nyog. Cov tshuaj tiv thaiv inhibited yog ib txwm tsim nyog hauv cov kab mob no rau kev sib txuas ntawm folic acid.
sulfonamides cuam tshuam dab tsi?
Sulfonamides cuam tshuam nrog tsim ntawm folic acid, ib qho tseem ceeb precursor rau nucleic acid synthesis. Cov hluavtaws pyrimidine derivative, trimethoprim, inhibits qhov kev ua ntawm dihydrofolate reductase, ib kauj ruam tom ntej hauv txoj kev anabolic no.
Dab tsi yog sulfonamides tiv thaiv?
Sulfonamides muaj txiaj ntsig tiv thaiv Gram-positive thiab Gram-negative bacteria. Qee cov protozoa, xws li coccidians, Toxoplasma hom thiab plasmodia, feem ntau rhiab heev. Cov kab mob Chlamydia, Nocardia thiab Actinomyces kuj rhiab heev.
