Kho cov qib ntawm ceftriaxone txo qis albumin concentration hauv cov ntshav yug menyuam los ntawm 39%. Cov txiaj ntsig no qhia tau hais tias ceftriaxone tuaj yeem ua rau muaj kev pheej hmoo ntawm bilirubin encephalopathy bilirubin encephalopathy Ib qho tsis muaj cov tsos mob ntawm tus mob neurologic yog tus yam ntxwv ntawm cov menyuam mos yug ntxov nrog kernicterus. Cov tsos mob ntawm tus mob neurologic ntawm lub sij hawm me nyuam mos uas muaj cim hyperbilirubinemia muaj xws li qhov txawv txav ntawm kev nco qab, cov leeg nqaij thiab kev txav, thiab lub hlwb ua haujlwm, xws li pub mis thiab quaj. https://pediatrics.aappublications.org › content
Kernicterus nyob rau hauv cov menyuam mos yug ntxov | American Academy of Pediatrics
hauv cov menyuam mos liab ntxov ntxov.
Ceftriaxone ua rau jaundice li cas?
Ceftriaxone ua rau txo qis ntawm cov tshuaj bilirubin tsis sib xws thiab ib txhij nce ntawm erythrocyte-bound bilirubin. Cov kev hloov pauv no yog qhov tseem ceeb tshaj plaws rau cov tshuaj tua kab mob qis, suav nrog cov txiaj ntsig kho mob.
Puas ceftriaxone cuam tshuam rau daim siab?
Cephalosporin-induced hepatoxicity tsis tshua pom. Cov teebmeem tshwm sim feem ntau yog gallstones (cholelithiasis) lossis cov kua tsib. Txawm tias muaj tseeb hais tias tsuas yog ob peb kis ntawm siab siab enzymes los ntawm ceftriaxone tau raug tshaj tawm[2–4], tsuas yog peb kis kab mob siab tau tshaj tawm nyob rau hauv cov ntaub ntawv[2–4].
Cov tshuaj tua kab mob puas tuaj yeem nce ncaj qha bilirubin?
Cov tshuaj uas tuaj yeem nce kev ntsuas bilirubin suav nrog allopurinol, anabolic steroids, qee cov tshuaj tua kab mob, tshuaj tiv thaiv kab mob, azathioprine, chlorpropamide, cholinergics, codeine, diuretics, epinephrine, meperidine, methotrexate, methyldopa, MAO inhibitors, morphine, ornicottraceptives., phenothiazine, …
Tus kab mob ua rau hyperbilirubinemia li cas?
Cov cytokines no, kuj yog vim li cas rau o thaum lub sij hawm sepsis, cuam tshuam peb lub cev lub peev xwm los tswj bilirubin. Yog li ntawd, peb lub cev tsis tuaj yeem ua cov tshuaj bilirubin ib txwm, ua rau tsim ntawm bilirubin, uas ua rau tawv nqaij daj, los yog jaundice.
