Thaum kawg, fibroblastic reticular cells (FRCs) nthuav qhia thiab nthuav tawm cov ntaub so ntswg peripheral txwv antigen rau T cov hlwb ua ib feem ntawm peripheral tolerance mechanism, thiab lawv lub peev xwm los txhawb T hlwb yog Hloov pauv nyob ntawm qhov mob ntawm cov ntaub so ntswg (56).
Cov hlwb twg tuaj yeem ua raws li cov tshuaj tiv thaiv kab mob?
Cov hom tseem ceeb ntawm cov neeg ua haujlwm antigen-presenting cells yog dendritic cells, macrophages thiab B cells.
Cov tshuaj tiv thaiv puas tuaj yeem ua cov tshuaj tiv thaiv kab mob?
Nyob rau hauv cov tshuaj tiv thaiv kab mob thib ob, nco B hlwb lawv tus kheej tuaj yeem ua raws li cov tshuaj tiv thaiv tam sim no thiab qhib cov pab T hlwb, nrog rau ua lub hom phiaj tom ntej ntawm tus pab cuam T cells..
Yuav ua li cas rau cov tshuaj tiv thaiv kab mob tam sim no?
Ib qho tshuaj tiv thaiv kab mob tam sim no (APC) yog lub cev tiv thaiv kab mob uas ntes, engulfs, thiab qhia txog kev hloov lub cev tiv thaiv kab mob txog tus kab mob. Thaum kuaj pom tus kab mob, cov APCs no yuav phagocytose cov kab mob thiab zom nws los ua ntau qhov sib txawv ntawm cov tshuaj tiv thaiv.
Puas yog cov tshuaj tua kab mob ntuj tsim cov tshuaj tiv thaiv kab mob?
Antigen kev nthuav qhia los ntawm NK hlwb induced ib tug polyfunctional CD4 + T cell activation, zoo li zoo li uas tau pom thaum siv moDC li APCs, tus yam ntxwv los ntawm zus tau tej cov Th1 cytokines thiab tso tawm ntawm lawv cytotoxic granules, nyob rau hauv ib feem ntawm lub tshuab txais lub hlwb.
