Ib txoj haujlwm tseem ceeb ntawm nicotinic receptors yog txhawm rau ua kom sai sai ntawm cov paj hlwb thiab neuromuscular kisNicotinic receptors muaj nyob rau hauv: Lub paj hlwb somatic (neuromuscular junctions hauv cov leeg pob txha). Lub sympathetic thiab parasympathetic paj hlwb (autonomic ganglia).
Nicotinic receptors koom nrog dab tsi?
Nicotinic acetylcholine receptors, lossis nAChRs, yog cov receptor polypeptides uas teb rau cov neurotransmitter acetylcholine Nicotinic receptors kuj teb rau cov tshuaj xws li agonist nicotine. Lawv muaj nyob rau hauv nruab nrab thiab peripheral paj hlwb, nqaij, thiab ntau lwm yam ntaub so ntswg ntawm ntau yam kab mob.
Yuav ua li cas nicotinic receptors tso tawm?
Ntau cov nicotinic receptors tshwm sim los hloov pauv neurotransmitter tso tawmlos ntawm kev ua kom muaj zog. Presynaptic receptors yuav muab cov tswv yim tawm tswv yim ntawm kev tso tawm transmitter. Xws li kev ua presynaptic cuam tshuam rau kev tso tawm ntawm acetylcholine, dopamine, noradrenaline, serotonin, γ-aminobutyric acid, thiab glutamate.
Vim li cas nicotinic receptors tseem ceeb?
Nicotinic receptors tau muab faib ua ntau yam neurotransmitter systems ntawm ntau tshaj ib qhov chaw, thiab qhov dav, tab sis sparse, cholinergic innervation thoob plaws hauv lub hlwb kom ntseeg tau tias nicotinic acetylcholine receptors yog tseem ceeb modulators ntawm neuronal excitability
Yuav ua li cas thaum nicotinic receptors raug thaiv?
Nicotinic antagonists block synaptic kis tau tus mob ntawm autonomic ganglia, lub pob txha neuromuscular hlws ris, thiab hauv nruab nrab paj hlwb nicotinic synapses. Ib qho nondepolarizing paj blocker siv ntxiv rau cov tshuaj loog ua rau cov leeg pob txha so.
