Txawm hais tias lub hom phiaj tseem ceeb ntawm tus kab mob HIV yog CD4+ T hlwb, dendritic cells (DC) sawv cev rau tseem ceeb subsethauv kev kis kab mob HIV vim lawv cuam tshuam kev kis tus kab mob, lub hom phiaj kab mob ntawm tes thiab antigen. kev nthuav qhia ntawm HIV antigens.
Puas yog macrophages thiab dendritic hlwb kis los ntawm HIV?
Monocyte-derived dendritic cells thiab DC-SIGN transfectants tuaj yeem ntes thiab xa HIV mus rau lub hom phiaj cells yam tsis muaj lawv tus kheej kis tus kab mob Qhov no tso cai hloov cov kab mob los ntawm hom cell uas ntes, tab sis tsis kis kab mob, ntawm DC-SIGN lossis lwm yam kab mob HIV.
HIV puas kis tau rau lwm lub hlwb?
HIV kis kab mob tiv thaiv kab mob uas muaj CD4 receptor nyob rau saum npoo. Cov hlwb no suav nrog T-lymphocytes (tseem hu ua t cells), monocytes, macrophages thiab dendritic cells. CD4 receptor yog siv los ntawm lub xovtooj ntawm tes los qhia rau lwm qhov chaw ntawm lub cev tiv thaiv kab mob muaj antigens.
Cov kab mob dendritic puas kis tau?
Lawv sau cov kab mob antigens (cov protein tshwj xeeb rau tus kab mob uas tau muab), thiab nthuav qhia lawv mus rau cov receptors ntawm T hlwb, uas ua rau txhawb kev hloov kho lub cev tiv thaiv kab mob rau tus kab mob ntawd. Tab sis ntawm txoj kev, DCs yog qhov yooj yim rau kev kis tus kab mob, xav tias yuav cuam tshuam lawv lub zog tiv thaiv.
HIV puas tuaj yeem kis tus kabmob macrophages?
Summary: HIV kis thiab rov tsim dua hauv macrophages, cov qe ntshav dawb loj pom nyob rau hauv daim siab, hlwb thiab cov ntaub so ntswg ntawm lub cev, kev tshawb fawb tshiab qhia. Qhov kev tshawb pom no muaj qhov cuam tshuam loj rau kev tshawb fawb kho HIV.
