Thrombin yog tsim los ntawm cov enzymatic cleavage ntawm ob qhov chaw ntawm prothrombin los ntawm activated Factor X (Xa). Cov kev ua ntawm Factor Xa tau zoo heev los ntawm kev khi rau activated Factor V (Va), hu ua prothrombinase complex.
Puas yog thrombin zoo ib yam li yam X?
Factor Xa yog qhov tseem ceeb ntawm cov prothrombinase complex uas hloov cov ntau ntawm prothrombin- "thrombin tawg". Txhua molecule ntawm Factor Xa tuaj yeem tsim 1000 molecules ntawm thrombin. Qhov tawg loj ntawm thrombin no yog lub luag haujlwm rau fibrin polymerization los ua ib qho thrombus.
Puas X tau qhib thrombin?
Nyob rau hauv ib-theem txheej txheem factor Xa activates prothrombin, nyob rau hauv lub xub ntiag ntawm factor V thiab phospholipids, rau thrombin uas converts qhia fibrinogen. rau fibrin. Lub sij hawm ua kua yog ntsuas.
Lub npe ntawm cov ntshav txhaws X yog dab tsi?
Factor X (fX), tseem hu ua Stuart factor, yog vitamin-K nyob ntawm serine protease zymogen uas tau qhib rau thawj kauj ruam ntawm txoj hauv kev thiab sab hauv ntawm ntshav coagulation.
Qhov twg yog cov ntaub so ntswg?
Tissue factor (TF) yog ib qho transmembrane receptor rau Factor VII/VIIa (FVII/VIIa) Nws yog constitutively qhia los ntawm cov hlwb nyob ib ncig ntawm cov hlab ntsha. Lub endothelium lub cev cais qhov muaj zog "activator" los ntawm nws cov ligand FVII / FVIIa thiab tiv thaiv kev ua kom tsis tsim nyog ntawm cov hlab ntsha.
