Insulin muaj ntau yam teebmeem hauv daim siab uas txhawb nqa glycogen synthesis. Ua ntej, nws qhib lub enzyme hexokinase, uas phosphorylates qabzib, ntxiab nws hauv cell.
Hexokinase ua haujlwm li cas?
Hexokinase activates glycoloysis los ntawm phosphorylating qabzib… Cov ntaub so ntswg uas muaj hexokinase siv cov piam thaj hauv cov ntshav qis. G6P inhibits hexokinase los ntawm kev khi rau N-terminal domain (qhov no yog kev tawm tswv yim yooj yim inhibition). Nws sib tw inhibits kev khi ntawm ATP [8].
YPuas insulin ua rau glucokinase lossis hexokinase?
Insulin zoo li cuam tshuam rau ob qho tib si glucokinase transcription thiab kev ua haujlwmlos ntawm ntau txoj hauv kev ncaj thiab tsis ncaj. Thaum nce qib portal leeg ntshav qabzib nce ntxiv kev ua haujlwm ntawm glucokinase, qhov sib xyaw ua ke ntawm cov tshuaj insulin ua kom cov nyhuv no los ntawm induction ntawm glucokinase synthesis.
Hexokinase inhibited los ntawm dab tsi?
Hexokinase, lub enzyme catalyzing thawj kauj ruam ntawm glycolysis, yog inhibited los ntawm nws cov khoom, glucose 6-phosphate.
YPuas insulin qhib glycolysis?
Insulin inhibits gluconeogenesis thiab glycogenolysis, stimulates glycolysis thiab glycogenesis, nkoos uptake thiab incorporation ntawm amino acids rau hauv protein, inhibits protein degradation, stimulates lipogenesis, thiab suppress lipolysis (Bassett, 1975).. (1975).
