Kev tshem tawm ntawm warfarin yuav luag tag nrho los ntawm cov metabolism. COUMADIN yog stereoselectively metabolized los ntawm hepatic microsomal enzymes(cytochrome P-450) rau inactive hydroxylated metabolites (feem ntau txoj kev) thiab los ntawm reductases kom txo cov metabolites (warfarin alcohols).
YPuas yog warfarin metabolized hauv daim siab?
(Warfarin yog metabolized hauv daim siab. CYP1A1, CYP1A2, thiab CYP3A4 metabolizes (R)-enantiomer thiab CYP2C9 metabolizes lub zog ntau dua (S)-enantiomer.
Warfarin metabolized nyob qhov twg?
Warfarin accumulates hauv lub siab, qhov twg ob isomers tau metabolized ntawm txoj kev sib txawv. Oxidative metabolism ntawm cov nquag S isomer yog cuam tshuam los ntawm CYP2C9.
Cov tshuaj tiv thaiv coagulants metabolized nyob qhov twg?
Qhov ncauj anticoagulants yog metabolized los ntawm lub siabthiab tawm hauv cov zis thiab quav.
YPuas yog warfarin metabolized los ntawm CYP2C9?
Warfarin yog tswj hwm raws li kev sib tw sib tw ntawm R thiab S stereoisomers. (S)-warfarin yog ob mus rau tsib npaug ntau zog tshaj (R)-warfarin, thiab feem ntau metabolized los ntawm CYP2C9 (R)-warfarin feem ntau metabolized ntawm CYP3A4, nrog kev koom tes ntawm ob peb. Lwm yam cytochrome P450 enzymes (6).
