Cov txheej txheem:
- YPuas yog warfarin metabolized hauv daim siab?
- Warfarin metabolized nyob qhov twg?
- Cov tshuaj tiv thaiv coagulants metabolized nyob qhov twg?
- YPuas yog warfarin metabolized los ntawm CYP2C9?
Video: Qhov twg yog coumadin metabolized?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Kev tshem tawm ntawm warfarin yuav luag tag nrho los ntawm cov metabolism. COUMADIN yog stereoselectively metabolized los ntawm hepatic microsomal enzymes(cytochrome P-450) rau inactive hydroxylated metabolites (feem ntau txoj kev) thiab los ntawm reductases kom txo cov metabolites (warfarin alcohols).
YPuas yog warfarin metabolized hauv daim siab?
(Warfarin yog metabolized hauv daim siab. CYP1A1, CYP1A2, thiab CYP3A4 metabolizes (R)-enantiomer thiab CYP2C9 metabolizes lub zog ntau dua (S)-enantiomer.
Warfarin metabolized nyob qhov twg?
Warfarin accumulates hauv lub siab, qhov twg ob isomers tau metabolized ntawm txoj kev sib txawv. Oxidative metabolism ntawm cov nquag S isomer yog cuam tshuam los ntawm CYP2C9.
Cov tshuaj tiv thaiv coagulants metabolized nyob qhov twg?
Qhov ncauj anticoagulants yog metabolized los ntawm lub siabthiab tawm hauv cov zis thiab quav.
YPuas yog warfarin metabolized los ntawm CYP2C9?
Warfarin yog tswj hwm raws li kev sib tw sib tw ntawm R thiab S stereoisomers. (S)-warfarin yog ob mus rau tsib npaug ntau zog tshaj (R)-warfarin, thiab feem ntau metabolized los ntawm CYP2C9 (R)-warfarin feem ntau metabolized ntawm CYP3A4, nrog kev koom tes ntawm ob peb. Lwm yam cytochrome P450 enzymes (6).
Pom zoo:
Qhov twg yog tshuaj tiv thaiv kab mob metabolized?
Cov metabolism ntawm quetiapine tshwm sim ntawm txoj kab siab, feem ntau yog los ntawm CYP3A4 isoenzyme hauv cytochrome P450 thiab kev tso tawm tshwm sim feem ntau ntawm lub raum txoj kev, nrog rau feem pua ntawm kwv yees li 20% yog tawm los ntawm faeces (DeVane thiab Nemeroff, 2001;
Dilaudid metabolized nyob qhov twg?
Hydromorphone feem ntau metabolized los ntawm glucuronidation hauv lub siab, nrog ntau dua 95% ntawm cov tshuaj metabolized rau hydromorphone-3-glucuronide nrog rau me me ntawm 6-hydroxy txo cov metabolites. Tsuas yog ib qho me me ntawm cov koob tshuaj hydromorphone raug tso tawm tsis hloov pauv hauv cov zis .
Qhov twg yog qhov mob thiab qhov twg yog qhov ceeb?
Panic (lub suab los ntawm Matt Frewer) yog lub ntsej muag ntsuab-xiav nrog lub cev ntev. Thaum nws yog me ntsis cunning dua Pain, nws paranoia txhais tau hais tias nws yog heev ceev faj thiab ntau cynical nyob rau hauv lub sij hawm, yog li nws tej zaum yuav ntse dua ib tug ntawm ob.
Puas yog ibuprofen metabolized hauv ob lub raum?
Ibuprofen, ntawm qhov tod tes, yog tshem tawm ntawm koj lub cev los ntawm koj lub raum. Kev siv sijhawm ntev tuaj yeem ua rau lub raum puas thiab plab los ntshav . Puas yog ibuprofen metabolized hauv daim siab lossis raum? Ibuprofen thiab lwm yam NSAIDs tsis tshua muaj kev cuam tshuam rau daim siab.
Vancomycin metabolized nyob qhov twg?
Cov txiaj ntsig tau lees paub tias vancomycin tsis metabolized hauv daim siabthiab feem ntau ntawm vancomycin noj hauv lub cev tau tawm hauv cov zis. Qhov kev poob qis tshaj plaws ntawm vancomycin yog nyob rau hauv nas lub siab microsomes, uas tau degraded 50% nyob rau hauv kwv yees li 6 hnub .
