Cov txheej txheem:
- Yuav ua li cas cov tshuaj tiv thaiv kab mob metabolized?
- Puas yog tshuaj tiv thaiv kab mob raum tshem tawm?
- tshuaj tiv thaiv puas siab puas ntsws nyob qhov twg?
- Qhov twg atypical antipsychotics feem ntau metabolized los ntawm daim siab?
Video: Qhov twg yog tshuaj tiv thaiv kab mob metabolized?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
… Cov metabolism ntawm quetiapine tshwm sim ntawm txoj kab siab, feem ntau yog los ntawm CYP3A4 isoenzyme hauv cytochrome P450 thiab kev tso tawm tshwm sim feem ntau ntawm lub raum txoj kev, nrog rau feem pua ntawm kwv yees li 20% yog tawm los ntawm faeces (DeVane thiab Nemeroff, 2001; Sheehan li al., 2010; López-Muñoz thiab Alamo, 2013).
Yuav ua li cas cov tshuaj tiv thaiv kab mob metabolized?
Risperidone yog metabolized feem ntau los ntawm CYP2D6 thiab kom tsawg dua los ntawm CYP3A4; 9-hydroxy metabolite ntawm risperidone (paliperidone) yog tam sim no ua lag luam raws li cov tshuaj tiv thaiv kab mob hauv nws tus kheej txoj cai. Olanzapine yog metabolized feem ntau los ntawm glucuronidation ncaj qha thiab CYP1A2 thiab tsawg dua los ntawm CYP2D6 thiab CYP3A4.
Puas yog tshuaj tiv thaiv kab mob raum tshem tawm?
Haloperidol yog suav tias muaj kev nyab xeeb hauv lub raum kab mob vim tias <1% ntawm cov tshuaj raug tshem tawm tsis hloov pauv los ntawm cov zis. Thib ob tiam antipsychotics (SGAs). Zuag qhia tag nrho, SGAs raug suav hais tias muaj kev nyab xeeb rau cov neeg mob lub raum.
tshuaj tiv thaiv puas siab puas ntsws nyob qhov twg?
Feem ntau ntawm cov tshuaj tiv thaiv kab mob yog lipophilic heev thiab hla lipoidal daim nyias nyias dawb. Thaum muab tshuaj rau qhov ncauj, lawv tau nqus tau zoo thiab tau txais kev tshem tawm ua ntej ntawm lub cev (bioavailability: 10-70%), yog khi rau cov ntshav plasma protein ntau (75-99%) thiab cov ntaub so ntswg, thiab tau faib ntau heev (VD: 100-1000 L).
Qhov twg atypical antipsychotics feem ntau metabolized los ntawm daim siab?
Feem ntau APs yog cov metabolized hepatically los ntawm CYP2D6 thiab CYP3A4, txawm hais tias clozapine thiab olanzapine feem ntau metabolized ntawm CYP1A2. Clozapine tau pom tias inhibit CYPs 2C19, 2D6, thiab 3A4, thiab yog li ntawd muaj peev xwm ua rau cov tshuaj pharmacokinetic-tshuaj sib cuam tshuam (Urichuk li al.
Pom zoo:
Puas yog cov tshuaj tiv thaiv kab mob sib txuas tau suav tias yog kev tiv thaiv kab mob?
Antibody drug conjugates (ADCs) yog ib hom tshuaj tiv thaiv kab mob. Lawv yog tsim los ntawm peb yam: monoclonal antibody (mAb) thiab cytotoxic payload ua los ntawm cov kws khomob kws khomob, uas txuas nrog ua ke siv cov tshuaj sib txuas . Puas yog tshuaj tiv thaiv kab mob tib yam li kev tiv thaiv kab mob?
Puas yog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob ua rau lupus?
Antinuclear cov tshuaj tiv thaiv yog autoantibodies - cov tshuaj tiv thaiv kab mob uas tsom rau cov proteins ib txwm nyob hauv lub hauv paus ntawm lub cell. Qhov no dhau los ua qhov tseem ceeb hauv kev kho mob thaum ANAs teeb liab lub cevpib tsom nws tus kheej, uas tuaj yeem ua rau cov kab mob autoimmune, suav nrog lupus, Sjogren's syndrome, thiab cov kab mob sib xyaw ua ke .
Cov neeg mob tiv thaiv kab mob yuav tsum tau txais cov tshuaj tiv thaiv?
Vim li cas CDC thiaj pom zoo tias cov neeg uas muaj kev tiv thaiv kab mob tiv thaiv kab mob tau txais koob tshuaj mRNA COVID-19 ntxiv los ntxiv rau 2-dose thawj koob tshuaj tiv thaiv kab mob mRNA COVID-19? Cov neeg uas muaj kev tiv thaiv kab mob los yog cov neeg siv tshuaj tiv thaiv kab mob yog nyob ntawm muaj kev pheej hmoo ntau rau tus kab mob COVID-19 hnyav .
Ntawm kev kuaj tshuaj tiv thaiv kab mob tiv thaiv kab mob?
Kev kuaj mob hnyav yog siv los txiav txim seb cov tshuaj tua kab mob twg yuav cuam tshuam kev loj hlob ntawm cov kab mob lossis cov kab mob ua rau muaj kab mob tshwj xeebCov txiaj ntsig ntawm qhov kev sim no yuav pab tus kws kho mob txiav txim siab seb cov tshuaj twg yog yuav ua tau zoo tshaj plaws hauv kev kho tus neeg mob .
Cov tshuaj tiv thaiv kab mob puas muaj kev tiv thaiv kab mob?
Nws yuav siv sijhawm ntev npaum li cas txhawm rau txhim kho kev tiv thaiv kab mob COVID-19 tom qab tau txais cov tshuaj tiv thaiv? tshuaj tiv thaiv COVID-19 qhia peb lub cev tiv thaiv kab mob kom paub txog thiab tawm tsam tus kab mob uas ua rau COVID-19.
