… Cov metabolism ntawm quetiapine tshwm sim ntawm txoj kab siab, feem ntau yog los ntawm CYP3A4 isoenzyme hauv cytochrome P450 thiab kev tso tawm tshwm sim feem ntau ntawm lub raum txoj kev, nrog rau feem pua ntawm kwv yees li 20% yog tawm los ntawm faeces (DeVane thiab Nemeroff, 2001; Sheehan li al., 2010; López-Muñoz thiab Alamo, 2013).
Yuav ua li cas cov tshuaj tiv thaiv kab mob metabolized?
Risperidone yog metabolized feem ntau los ntawm CYP2D6 thiab kom tsawg dua los ntawm CYP3A4; 9-hydroxy metabolite ntawm risperidone (paliperidone) yog tam sim no ua lag luam raws li cov tshuaj tiv thaiv kab mob hauv nws tus kheej txoj cai. Olanzapine yog metabolized feem ntau los ntawm glucuronidation ncaj qha thiab CYP1A2 thiab tsawg dua los ntawm CYP2D6 thiab CYP3A4.
Puas yog tshuaj tiv thaiv kab mob raum tshem tawm?
Haloperidol yog suav tias muaj kev nyab xeeb hauv lub raum kab mob vim tias <1% ntawm cov tshuaj raug tshem tawm tsis hloov pauv los ntawm cov zis. Thib ob tiam antipsychotics (SGAs). Zuag qhia tag nrho, SGAs raug suav hais tias muaj kev nyab xeeb rau cov neeg mob lub raum.
tshuaj tiv thaiv puas siab puas ntsws nyob qhov twg?
Feem ntau ntawm cov tshuaj tiv thaiv kab mob yog lipophilic heev thiab hla lipoidal daim nyias nyias dawb. Thaum muab tshuaj rau qhov ncauj, lawv tau nqus tau zoo thiab tau txais kev tshem tawm ua ntej ntawm lub cev (bioavailability: 10-70%), yog khi rau cov ntshav plasma protein ntau (75-99%) thiab cov ntaub so ntswg, thiab tau faib ntau heev (VD: 100-1000 L).
Qhov twg atypical antipsychotics feem ntau metabolized los ntawm daim siab?
Feem ntau APs yog cov metabolized hepatically los ntawm CYP2D6 thiab CYP3A4, txawm hais tias clozapine thiab olanzapine feem ntau metabolized ntawm CYP1A2. Clozapine tau pom tias inhibit CYPs 2C19, 2D6, thiab 3A4, thiab yog li ntawd muaj peev xwm ua rau cov tshuaj pharmacokinetic-tshuaj sib cuam tshuam (Urichuk li al.
