Ob leeg vincristine thiab vinblastine khi rau lub microtubular microtubular Lawv yog tsim los ntawm cov polymerization ntawm ib tug dimer ntawm ob lub globular proteins, alpha thiab beta tubulin rau hauv protofilaments uas tuaj yeem koom nrog tom qab. tsim ib tug hollow raj, lub microtubule. Daim ntawv feem ntau ntawm microtubule muaj 13 protofilaments nyob rau hauv tubular kev npaj. https://en.wikipedia.org › wiki › Microtubule
Microtubule - Wikipedia
proteins ntawm mitotic spindle thiab tiv thaiv cell faib thaum lub sij hawm anaphase ntawm mitosis. Lawv ntes mitosis thiab ua rau cell tuag. Cov tshuaj yog li M-phase cell-cycle tshwj xeeb thiab lawv cov teebmeem yog li txwv rau kev faib hlwb.
Vincristine ua dab tsi rau cov hlwb?
Nws ua haujlwm li cas. Vincristine yog ib qho tshuaj khomob uas muaj nyob rau hauv ib pawg tshuaj hu ua vinca alkaloids. Vincristine ua haujlwm los ntawm kev txwv tsis pub cov qog nqaij hlav qog noj ntshav sib cais ua 2 lub hlwb tshiab. Yog li, nws nres qhov kev loj hlob ntawm cov qog nqaij hlav.
Vim li cas vincristine puas ua rau lub mitotic spindle?
Antimicrotubule cov neeg ua haujlwm (xws li Vincristine), txwv tsis pub cov qauv microtubule hauv cell. Microtubules yog ib feem ntawm lub xov tooj ntawm tes apparatus rau kev faib thiab replicating nws tus kheej. Inhibition ntawm cov qauv no thaum kawg ua rau cell tuag.
Puas siv tshuaj khomob inhibit mitosis?
Tshuaj xws li Taxol (Paclitaxel) tau siv zoo heev hauv kev kho mob vim tias lawv tshuaj lom microtubles thiab inhibit cov mitotic spindleQhov no txwv tsis pub cov qog nqaij hlav qog noj ntshav sib faib thiab ua rau lawv tuag. Txawm li cas los xij, qhov tsis zoo yog tias microtubules xav tau rau ntau lub luag haujlwm hauv cov hlwb uas tsis yog mob qog noj ntshav.
Tshuaj khomob cuam tshuam li cas mitosis?
Vim tias cov qog nqaij hlav qog noj ntshav sib faib ntau ntau dua li feem ntau cov hlwb, cov tshuaj khomob yog yuav tua tau ntau duaQee cov tshuaj tua cov cell faib los ntawm kev puas tsuaj ntawm cov cell tswj chaw uas ua rau nws faib. Lwm yam tshuaj cuam tshuam cov txheej txheem tshuaj lom neeg hauv kev faib cell.
