Nrawm INH hepatotoxicity tshwm sim nyob rau hauv induction ntawm hepatocyte apoptosis, nrog cuam tshuam cuam tshuam ntawm mitochondrial membrane muaj peev xwm thiab DNA strand so. Qhov feem ntau yuav biochemical mechanism yog tias cov metabolism hauv INH tsim cov metabolites reactive uas khi thiab puas cellular macromolecules nyob rau hauv daim siab.
Puas yog isoniazid ua rau muaj kab mob hepatotoxicity?
Isoniazid (INH; isonicotinylhydrazide lossis isonicotinic acid hydrazine) yog cov tshuaj tua kab mob hluavtaws uas muaj peev xwm tiv thaiv kab mob rov ua dua Mycobacterium tuberculosis. INH txij li thaum muaj kev cuam tshuam nrog ob tus kab mob siab hepatotoxicity: mob INH hepatotoxicity thiab INH kab mob siab[1-3].
Qhov twg yog hepatotoxic isoniazid lossis rifampicin ntau dua?
Hauv kev tshuaj ntsuam meta, isoniazid yog feem ntau yuav cuam tshuam nrog hepatotoxicity (qhov txawv ntawm qhov sib txawv (los yog) 1.6) txawm tias tsis muaj rifampicin, tab sis kev sib xyaw ntawm cov no. ob cov tshuaj tau txuam nrog ntau dua ntawm hepatotoxicity (LOSSIS 2.6) thaum piv rau txhua yam tshuaj ntawm nws tus kheej.
Yuav tshuaj tiv thaiv kab mob TB twg ua rau mob hepatotoxicity?
Ntawm cov thawj kab tshuaj tiv thaiv kab mob TB, isoniazid, rifampicin, thiab pyrazinamide paub tias ua rau hepatotoxicity, tab sis pyrazinamide tus cwj pwm rau feem pua ntawm cov tshuaj uas ua rau lub siab ua rau mob siab. piv rau lwm yam tshuaj.
Puas yog isoniazid ua rau muaj mob neurotoxicity?
Isoniazid tsis ua rau muaj kev cuam tshuam rau neurotoxicity thaum raug mus txog 7 hnub. Hydrazine tau pom tias yog cov tshuaj lom neeg metabolite tshaj plaws nrog LC50 qhov tseem ceeb ntawm 2.7 mM thiab 0.3 mM tom qab 7 hnub ntawm kev cuam tshuam hauv DRG neurons thiab N18D3 hybrid neurons, feem.
