Cov txheej txheem:
- Puas yog isoniazid ua rau muaj kab mob hepatotoxicity?
- Qhov twg yog hepatotoxic isoniazid lossis rifampicin ntau dua?
- Yuav tshuaj tiv thaiv kab mob TB twg ua rau mob hepatotoxicity?
- Puas yog isoniazid ua rau muaj mob neurotoxicity?
Video: Vim li cas isoniazid ua rau mob hepatotoxicity?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Nrawm INH hepatotoxicity tshwm sim nyob rau hauv induction ntawm hepatocyte apoptosis, nrog cuam tshuam cuam tshuam ntawm mitochondrial membrane muaj peev xwm thiab DNA strand so. Qhov feem ntau yuav biochemical mechanism yog tias cov metabolism hauv INH tsim cov metabolites reactive uas khi thiab puas cellular macromolecules nyob rau hauv daim siab.
Puas yog isoniazid ua rau muaj kab mob hepatotoxicity?
Isoniazid (INH; isonicotinylhydrazide lossis isonicotinic acid hydrazine) yog cov tshuaj tua kab mob hluavtaws uas muaj peev xwm tiv thaiv kab mob rov ua dua Mycobacterium tuberculosis. INH txij li thaum muaj kev cuam tshuam nrog ob tus kab mob siab hepatotoxicity: mob INH hepatotoxicity thiab INH kab mob siab[1-3].
Qhov twg yog hepatotoxic isoniazid lossis rifampicin ntau dua?
Hauv kev tshuaj ntsuam meta, isoniazid yog feem ntau yuav cuam tshuam nrog hepatotoxicity (qhov txawv ntawm qhov sib txawv (los yog) 1.6) txawm tias tsis muaj rifampicin, tab sis kev sib xyaw ntawm cov no. ob cov tshuaj tau txuam nrog ntau dua ntawm hepatotoxicity (LOSSIS 2.6) thaum piv rau txhua yam tshuaj ntawm nws tus kheej.
Yuav tshuaj tiv thaiv kab mob TB twg ua rau mob hepatotoxicity?
Ntawm cov thawj kab tshuaj tiv thaiv kab mob TB, isoniazid, rifampicin, thiab pyrazinamide paub tias ua rau hepatotoxicity, tab sis pyrazinamide tus cwj pwm rau feem pua ntawm cov tshuaj uas ua rau lub siab ua rau mob siab. piv rau lwm yam tshuaj.
Puas yog isoniazid ua rau muaj mob neurotoxicity?
Isoniazid tsis ua rau muaj kev cuam tshuam rau neurotoxicity thaum raug mus txog 7 hnub. Hydrazine tau pom tias yog cov tshuaj lom neeg metabolite tshaj plaws nrog LC50 qhov tseem ceeb ntawm 2.7 mM thiab 0.3 mM tom qab 7 hnub ntawm kev cuam tshuam hauv DRG neurons thiab N18D3 hybrid neurons, feem.
Pom zoo:
Vim li cas tus neeg mob lub duav ua rau mob?
Hip tendonitis, tendinopathy, lossis abductor kua muag feem ntau tshwm sim los ntawm kev siv ntau dhau thaum ua si kis las uas yuav tsum tau dhia ntauHip tendonitis tuaj yeem tshwm sim yog tias cov leeg txhawb nqa nyob ze dhau lawm qaug zog los yog muaj zog heev, ua rau cov leeg tsis muaj zog.
Kab mob raum mob ua rau mob ntshav qab zib li cas?
cov qe ntshav liab yog tsim los ntawm cov pob txha pob txha. Txhawm rau kom cov pob txha los ua cov qe ntshav liab, lub raum ua cov tshuaj hu ua erythropoietin, lossis EPO. Thaum lub raum puas lawm, lawv yuav ua tsis tau EPO txaus. Yog tsis muaj EPO txaus, pob txha pob txha tsis ua kom liab txauscov qe ntshav, thiab koj muaj ntshav liab .
Vim li cas kuv tus kab mob ua rau mob ntev?
Feem ntau, cov kab mob tshwm sim thaum mob nqaij hlav, xws li thaum ncaws, pivoting lossis skating. Yam uas tuaj yeem ua rau tus neeg mob raug mob muaj xws li tsis ua kom sov, ncab kom zoo, lossis qaug zog los ntawm kev siv ntau dhau . Yuav ua li cas kho cov kab mob ntev ntev?
Yuav ua li cas txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau?
Ntau tus neeg ua tiav lawv txoj kev kho hniav thiab muaj cov hniav zoo nkauj, txawm li cas los xij, thaum lawv luag ntxhi lawv pom cov hniav luv luv lossis cov pos hniav ntau dhau "gummy luag". Cosmetic crown lengthening yog ib txoj hauv kev yooj yim uas tuaj yeem ua tau zoo heev ua kom lub ntsej muag luag ntxhi ntawm cov neeg mob no .
Yuav ua li cas tiv thaiv kab mob hepatotoxicity?
Kev tiv thaiv tau txais kev tiv thaiv thiab kev kho kom zoo; Nws raug nquahu kom pib nrog kev sib xyaw tshuaj khomob uas muaj INH, RMP, thiab Pyrazinamide(PZA)-ib tus neeg mob hepatotoxic ntxiv- nrog lossis tsis muaj ethambutol rau thawj 2 mo ua raws li theem txuas ntxiv ntawm 4-6 lub hlis ntawm INH + RMP[
