Carbonylation yog hais txog cov tshuaj tiv thaiv uas qhia carbon monoxide rau hauv cov organic thiab inorganic substrates. Cov pa roj carbon monoxide muaj ntau thiab yooj yim reactive, yog li nws tau dav siv los ua cov tshuaj reactant hauv kev lag luam chemistry. Lub sij hawm carbonylation kuj yog hais txog oxidation ntawm protein sab chains.
Cov tshuaj tiv thaiv carbonylation yog dab tsi?
Carbonylation yog hais txog rau cov tshuaj tiv thaiv uas qhia cov pa roj carbon monoxide rau hauv cov organic thiab inorganic substrates Ntau cov tshuaj organic uas muaj txiaj ntsig zoo yog npaj los ntawm carbonylations, uas tuaj yeem xaiv cov tshuaj tiv thaiv zoo heev. Carbonylations tsim cov organic carbonyls, piv txwv li, cov tebchaw uas muaj C=O.
protein carbonylation yog dab tsi?
Protein carbonylation yog ib hom protein oxidation uas tuaj yeem txhawb nqa los ntawm cov pa oxygen reactive. Nws feem ntau yog hais txog cov txheej txheem uas tsim cov ketones reactive lossis aldehydes uas tuaj yeem cuam tshuam los ntawm 2, 4-dinitrophenylhydrazine (DNPH) los tsim hydrazones.
Leej twg pom cawv carbonylation?
Xyoo 1941, tus kws tshuaj German Reppe thiab nws cov neeg ua haujlwmpom tias carbonylation ntawm methanol tuaj yeem nqa tawm ntawm 500-700 bar thiab ntawm 250 C-270 C nrog carbonyl compounds ntawm VIIIB pawg hlau (hlau, cob alt, thiab npib tsib xee), halogens ua catalysts.
Yuav ua li cas peb thiaj tiv thaiv cov protein carbonylation?
Kev zam oxidizing tej yam kev mob, tshem tawm cov nucleic acids, thiab kev soj ntsuam sai ntawm cov qauvtuaj yeem tiv thaiv cov khoom cuav ntawm cov protein carbonyl ntsuas. Oxidative stress yog qhov tshwm sim los ntawm qhov tsis sib xws hauv pro- oxidant / antioxidant homeostasis uas ua rau nce qib ntawm cov tshuaj lom reactive oxygen.
