Alloxan-induced diabetes is a form of insulin-dependent diabetes mellitus uas tshwm sim los ntawm kev tswj hwm alloxan lossis txhaj rau tsiaj [78], [79]. Nws tau ua tiav induced nyob rau hauv ntau hom tsiaj; luav, nas, nas, liab, miv thiab dev [80], [81].
nas ua rau mob ntshav qab zib li cas?
Intra-venous txhaj ntawm 60mg / kg koob tshuaj Streptozotocinhauv cov laus wistar nas, ua rau pancreas o thiab thaum kawg ua rau degeneration hauv Langerhans islet beta hlwb thiab ua rau kev sim ntshav qab zib mellitus hauv 2-4 hnub.
Dab tsi yog qhov mob uas alloxan tau tshwm sim hauv cov nas sim?
Alloxan-Induced Diabetes Triggers the Development of Periodontal Disease hauv nas.
Puas alloxan-induced type 2 diabetes in nas?
Alloxan thiab STZ induce T1DM hauv cov laus nas. Tab sis koj tuaj yeem siv STZ hauv cov nas yug tshiab los ntxias T2DM. Alloxan tsis tuaj yeem siv los ntxias T2DM. Qee cov qauv muaj xws li fructose-fed, cov zaub mov muaj roj ntau tau noj raws li kev noj tshuaj tsawg ntawm STZ thiab STZ / nicotinamide.
Yuav ua li cas streptozotocin ua rau ntshav qab zib?
Mob ntshav qab zib yog tshwm sim los ntawm streptozotocin (STZ), ib qho glucosamine-nitrosourea compound tau los ntawm Streptomyces achromogenes uas yog siv los kho cov tshuaj kws khomob hauv kev kho mob pancreatic β cell carcinoma. STZ cuam tshuam rau pancreatic β hlwb, ua rau hypoinsulinemia thiab hyperglycemia.
