Ntawm cov kev sib txawv, N-alkylation ntawm amides nrog cawv yog cov txheej txheem txaus nyiam rau lawv cov synthesis vim cawv yog nkag tau, thiab dej yog tsim los ntawm cov khoom lag luam.
Yuav ua li cas nrog amides?
Amides tuaj yeem ua hydrolyzed rau hauv carboxylic acid thiab ammonia lossis aminelos ntawm cua sov hauv cov kua qaub lossis cov tshuaj aqueous yooj yim. Nyob rau hauv ob qho tib si, acid-base tshwm sim nrog cov khoom ua rau tag nrho cov tshuaj tiv thaiv irreversible.
Puas cawv ua rau muaj amine?
Thaum lub voj voog catalytic, ib qho cawv yog dehydrogenated rau cov sib txuas carbonyl, uas cuam tshuam nrog cov amine los tsim ib qho imine. Lub imine yog nyob rau hauv qhov txo qis mus rau alkylated amine thiab cov hlau complex ua rau qhov yuav tsum tau hydrogen shuttling.
Yuav ua li cas haus cawv mus rau amide?
Iridium-catalyzed hloov hydrogenation ntawm cawv thiab styrene thiab tom qab tsim ntawm ib qho oxime tso cai hloov cov cawv rau hauv amides hauv ib lub lauj kaub txheej txheem.
Amide puas tuaj yeem txo tau cawv?
N, N-disubstituted amides tuaj yeem raug txo kom aldehydes los ntawm kev siv ntau tshaj ntawm amide: R(CO)NRR' + LiAlH 4→ RCHO + HNRR' Nrog kev txo qis ntxiv cov cawv tau txais. Qee cov amides tuaj yeem txo qis rau aldehydes hauv Sonn-Müller txoj kev.
