Cov txheej txheem:
- Cov kws tshawb fawb tau tsim cov kab mob pluripotent qia hlwb li cas?
- Yuav ua rau pluripotent qia hlwb tuaj qhov twg?
- Dab tsi yog qhov tshwm sim thawj zaug pom los tsim cov kab mob pluripotent qia hlwb?
- Dab tsi yog siv los ua thawj zaug induced pluripotent qia cell?
Video: Leej twg nrhiav tau induced pluripotent qia hlwb?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Qhov kev tshawb pom ntawm induced pluripotent qia hlwb (iPSCs) los ntawm Shinya Yamanaka hauv 2006 tau tshaj tawm tias yog qhov kev tawg loj ntawm kaum xyoo hauv kev tshawb fawb qia hlwb.
Cov kws tshawb fawb tau tsim cov kab mob pluripotent qia hlwb li cas?
Induced pluripotent qia hlwb (iPS hlwb lossis iPSCs) yog hom pluripotent qia cell uas tuaj yeem tsim los ntawm cov neeg laus somatic hlwb xws li tawv nqaij fibrobalsts lossis peripheral ntshav mononuclear cells (PBMCs) los ntawm kev tshuaj ntsuam genetic reprograming los yog 'yuam' qhia txog cov noob caj noob ces (Oct4, Sox2, Klf4 thiab c-Myc)
Yuav ua rau pluripotent qia hlwb tuaj qhov twg?
Induced pluripotent qia (iPS) hlwb, yog ib hom pluripotent qia cell muab tau los ntawm cov neeg laus somatic hlwb uas tau raug genetically reprogrammed rau lub embryonic qia (ES) cell-zoo lixeev los ntawm kev yuam kev ntawm cov noob thiab cov yam tseem ceeb rau kev tswj xyuas lub ntsiab lus ntawm ES hlwb.
Dab tsi yog qhov tshwm sim thawj zaug pom los tsim cov kab mob pluripotent qia hlwb?
iPSCs piav qhia txog kev rov ua haujlwm ntawm cov hlwb somatic rau lub xeev pluripotent (Fig. 66.3Aii). Tus thawj iPSCs tau tsim los ntawm exogenously transducing plaub yam transcription: Oct4, Sox2, Klf4, thiab c-Myc hauv nas thiab tib neeg fibroblasts (Fig. 66.3B).
Dab tsi yog siv los ua thawj zaug induced pluripotent qia cell?
Lub sij hawm ntawm iPS cell technology tam sim no yuav muab cov qauv tshiab rau cov kab mob physiology hauv tib neeg lub siab thiab vascular system. Plaub qhov kev hloov pauv uas siv los ntawm Yamanaka los muab tib neeg iPS hlwb los ntawm fibroblasts yog OCT4, SOX2, KLF4 thiab C-MYC.
Pom zoo:
Mesenchymal qia hlwb tuaj yeem pom qhov twg?
Mesenchymal stem cells (MSCs) yog cov neeg laus qia hlwb ib txwm muaj nyob hauv pob txha pob txha. Txawm li cas los xij, mesenchymal qia hlwb tuaj yeem raug cais tawm ntawm lwm cov ntaub so ntswg nrog rau cov ntshav qaum, cov ntshav peripheral, hlab ntsha, thiab lub siab lub ntsws thiab lub ntsws .
Puas yog mesenchymal hlwb qia hlwb?
Mesenchymal qia hlwb yog multipotent neeg laus qia hlwb uas muaj nyob hauv ntau cov ntaub so ntswg, nrog rau txoj hlab ntaws, pob txha pob txha thiab cov nqaij rog. Mesenchymal qia hlwb tuaj yeem txuas ntxiv nws tus kheej los ntawm kev faib thiab tuaj yeem sib txawv rau ntau cov ntaub so ntswg nrog rau cov pob txha, pob txha mos, cov leeg nqaij thiab cov rog rog, thiab cov ntaub so ntswg sib txuas .
Cov neeg laus puas muaj pluripotent qia hlwb?
Kawg, pluripotent qia hlwb yog tam sim no hauv cov neeg laus cov ntaub so ntswg raws li feeb sub-populations hauv qee cov qia cell niches. Cov pej xeem zoo li no twb tau txheeb xyuas thiab tshaj tawm hauv cov pob txha pob txha muab tau los ntawm mesenchymal qia hlwb (Jiang li al.
Puas yog mesenchymal qia hlwb pluripotent lossis multipotent?
Mesenchymal stem cells (MSCs) yog ntau lub hlwb uas tuaj yeem sib txawv rau ntau hom cell, suav nrog pob txha, rog, pob txha mos, nqaij, thiab tawv nqaij (daim duab 14) . Puas yog mesenchymal qia hlwb pluripotent? Piv rau pluripotent qia hlwb nrog cuam tshuam kev pheej hmoo ntawm kev tiv thaiv kab mob tiv thaiv kab mob thiab tsim teratoma, cov neeg laus qia hlwb tshwj xeeb tshaj yog mesenchymal qia hlwb (MSCs) yog hyped los ua ib qho tsim nyog hloov vim lawv kuj nthu
Dab tsi yog induced pluripotent qia hlwb?
Induced pluripotent qia (iPS) hlwb, yog hom pluripotent qia cell muab tau los ntawm cov neeg laus somatic hlwb uas tau raug genetically reprogrammed mus rau lub embryonic qia (ES) cell-zoo li lub xeev los ntawm kev yuam kev. ntawm cov noob thiab yam tseem ceeb rau kev tswj hwm lub ntsiab lus ntawm ES hlwb .
