Tetanospasmin yog ib qho neurotoxin uas inhibits qhov tso tawm ntawm γ-aminobutyric acid (GABA) thiab ua rau muaj ntau yam kev kuaj mobfeem ntau cuam tshuam nrog tetanus nrog rau cov leeg nqaij spasms thiab rigidity, trismus. (lockjaw), dysphagia, tendon rupture, opisthotonus, ua pa nyuaj, thiab tuag (Cook li al., 2001).
Cov tshuaj tetanospasmin cuam tshuam li cas rau tus tswv tsev?
Thaum tetanospasmin nkag mus rau hauv cov hlab ntsha, nws kis tau sai heev nyob ib ncig ntawm lub cev, ua rau cov tsos mob tetanus. Tetanospasmin cuam tshuam nrog cov teeb liab taug kev los ntawm lub hlwb mus rau cov hlab ntsha hauv qaum qaum, thiab tom qab ntawd mus rau cov leeg, ua rau cov nqaij ntshiv thiab txhav
Tetanolysin ua rau lub cev puas tsuaj li cas?
Tetanolysin ua rau cov nqaij mos necrosis hauv zos uas yuav ua rau txo cov nqaij mos oxygenation thiab pab txhawb kev loj hlob ntawm cov kab mobTetanospasmin (TeNT) yog lub luag haujlwm rau cov tsos mob. Cov tshuaj lom yog thauj mus rau centripetally (ntawm axons ntawm lub cev muaj zog neurons) los ntawm qhov chaw qhia txog tus txha caj qaum.
Yuav ua li cas thauj cov tetanospasmin tshuaj lom neeg siv los ua tus kab mob?
Tetanus toxin kis los ntawm cov ntaub so ntswg mus rau hauv lub lymphatic thiab vascular systems. Nws nkag mus rau hauv lub paj hlwb ntawm cov neuromuscular junctions thiab migrates los ntawm cov hlab ntsha trunks thiab mus rau hauv lub hauv paus paj hlwb (CNS) los ntawm retrograde axonal thauj los ntawm kev siv dyneins
Tus kab mob tetanus ua haujlwm li cas?
Tetanus toxin raug coj mus rau hauv cov kab ke ntawm qis lub cev muaj zog neurons thiab thauj axonally mus rau qaum qaum thiab / lossis lub hlwb. Ntawm no cov co toxins txav trans-synaptically mus rau inhibitory paj hlwb terminals, qhov twg vesicular tso tawm ntawm inhibitory neurotransmitters ua thaiv, ua rau disinhibition ntawm qis lub cev muaj zog neurons.
