Methylglyoxal, ib qho tshuaj reactive dicarbonyl, yog inevitably tsim raws li a los ntawm cov khoom ntawm glycolysis… Xav txog qhov xav tau lub zog siab (piv txwv li, qabzib) ntawm lub hlwb, ib qho yuav tsum cia siab tias cerebral glyoxalase system yog tsim nyog los tswj methylglyoxal toxicity.
Methylglyoxal tsim nyob qhov twg?
Hauv cov kab mob, methylglyoxal yog tsim los ua ib qho khoom ntawm ob peb txoj hauv kev metabolic. Methylglyoxal feem ntau tshwm sim raws li cov khoom lag luam ntawm glycolysis suav nrog glyceraldehyde-3-phosphate thiab dihydroxyacetone phosphate. Nws kuj tseem xav tias yuav tshwm sim los ntawm kev degradation ntawm acetone thiab threonine.
methylglyoxal ua dab tsi hauv lub cev?
Methylglyoxal yog nws cov khoom xyaw nquag thiab yuav muaj lub luag haujlwm rau cov tshuaj tiv thaiv kab mob Tsis tas li ntawd, Manuka zib ntab muaj cov tshuaj tua kab mob, tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob antioxidant. Qhov tseeb, nws tau ib txwm siv los kho qhov txhab, soothing caj pas, tiv thaiv cov hniav lwj thiab txhim kho digestive teeb meem.
YPuas yog methylglyoxal ib qho enzyme?
Methylglyoxal (MG) yog cov tshuaj tiv thaiv cytotoxic alpha-oxoaldehyde heev thiab yog tsim endogenously ntawm txawv enzymatic thiab tsis-enzymatic cov tshuaj tiv thaivHauv cov nroj tsuag MG yog detoxified tsuas yog los ntawm glyoxalase system. uas muaj ob enzymes, glyoxalase I thiab glyoxalase II.
Puas yog methylglyoxal toxic?
Methylglyoxal yog tshuaj lom rau tib neeg cov hlwb neuroblastomanyob rau hauv ib koob tshuaj raws li qhov siab tshaj ntawm 0.15 mM nrog LD50 ntawm kwv yees li 1.25 mM.
