Protoporphyrin IX yog ib qho organic compound, cais raws li ib tug porphyrin, uas plays lub luag hauj lwm tseem ceeb nyob rau hauv cov kab mob nyob ua ib tug precursor rau lwm yam tseem ceeb tebchaw xws li heme thiab chlorophyll. Nws yog cov xim sib sib zog nqus uas tsis soluble hauv dej. Lub npe feem ntau yog luv li PPIX.
Kev ua haujlwm ntawm protoporphyrin yog dab tsi?
Protoporphyrin IX (PPIX) yog ib qho heterocyclic organic compound, uas muaj plaub pyrrole rings, thiab yog qhov kawg nruab nrab ntawm txoj kev heme biosynthetic. Nws cov qauv tetrapyrrole ua kom nws chelate hloov pauv hlau los ua metalloporphyrins, uas ua tau ntau yam kev ua haujlwm biologic.
Qhov txawv ntawm porphyrin thiab protoporphyrin yog dab tsi?
Qhov sib txawv tseem ceeb ntawm porphyrin thiab protoporphyrin yog porphyrin yog ib pawg tshuaj tsw qab uas muaj plaub qhov hloov pauv pyrrole subunits interconnected rau ib leeg, whereas protoporphyrin yog ib qho derivative ntawm porphyrin uas muaj propionic acid pawg.
Qhov twg ntawm cov porphyrins mus rau hauv kev tsim ntawm protoporphyrin IX?
Ob kauj ruam oxidation catalyzed los ntawm CP oxidase thiab protoporphyrinogen oxidase (PPOX) ua rau cov tsim ntawm protoporphyrin IX nyob rau hauv lub puab mitochondria membrane ntsib lub matrix.
Protoporphyrin tsim li cas?
Cov tshuaj ua ntej, protoporphyrin III yog synthesized los ntawm glycine thiab succinyl-CoAnyob rau hauv peb kauj ruam: (1) synthesis ntawm δ-aminolevulinic acid (ALA), (2) tsim ntawm porphobilinogen, thiab (3) synthesis ntawm protoporphyrin. Heme tau txais los ntawm kev ntxiv ib qho atom ntawm ferrous hlau rau protoporphyrin.
