[ah-set″ĭ-la´ter] ib qho kab mob muaj peev xwm ntawm metabolic acetylation. Cov tib neeg uas txawv ntawm lawv qhov peev xwm los ua metabolize qee yam tshuaj, xws li isoniazid, yog hu ua acetylators ceev lossis qeeb.
Dab tsi yog Acetylators nrawm thiab qeeb acetylators?
Cov acetylator phenotype qeeb qeeb feem ntau ntsib kev toxicity los ntawm cov tshuaj xws li isoniazid, sulfonamides, procainamide, thiab hydralazine, whereas tus ceev acetylator phenotype yuav tsis teb rau isoniazid thiab hydralazine nyob rau hauv kev tswj ntawm tuberculosis thiab kub siab, feem.
Lub ntsiab lus ntawm qeeb acetylators yog dab tsi?
Slow acetylators yog cov neeg uas nws lub siab tsis tuaj yeem tshem tawm cov tshuaj reactive metabolites Piv txwv li, cov neeg mob uas muaj sulfonamide-induced toxic epidermal necrolysis tau pom tias muaj qeeb acetylator genotype uas ua rau muaj kev tsim cov sulfonamide hydroxylamine ntau ntxiv ntawm txoj kev P-450.
Dab tsi yog qeeb thiab ceev acetylators piav qhia txog kev cuam tshuam rau acetylation ntawm isoniazid?
Metabolism ntawm isoniazid tshwm sim los ntawm acetylation. Hauv cov neeg mob uas muaj cov noob caj noob ces "ceev acetylators," isoniazid yuav tsis ncav cuag qib kho thiab yuav muaj cov plasma luv t ½piv nrog "slow acetylators. " Cov acetylators qeeb yuav muaj kev pheej hmoo ntau dua rau cov tshuaj toxicity vim yog cov tshuaj ntev t½
Pab twg ntawm cov tshuaj metabolized los ntawm acetylation?
Tshuaj uas paub tias metabolized los ntawm txoj kev no suav nrog procainamide, hydralazine, isoniazid, sulfapyridine, sulfadimidine, dapsone, amine metabolite ntawm nitrazepam, thiab qee qhov carcinogenic aromatic amines. Nongenetic yam tseem tuaj yeem cuam tshuam tus nqi ntawm acetylation.
