Plaub ntawm yim cephalosporinase-ua hom kab mob tau tiv taus cefoxitin, uas yog resistant tag nrho rau hydrolysis los ntawm β-lactamases. Cefozolin, cefamandole thiab cefazaflur inhibited ob peb hom kab mob no txawm tias kev puas tsuaj los ntawm β-lactamase.
Yam twg ntawm cephalosporins tiv taus beta-lactamases?
Cefoxitin, cefuroxime, thiab cephalosporins thib peb yog cov tshuaj tiv thaiv tshaj plaws rau beta-lactamases uas tsim los ntawm cov kab mob Gram-negative. Beta-lactamases uas tsim los ntawm cov kab mob Gram-negative yog chromosomal (chav kawm I beta-lactamases) los yog plasmid (chav kawm III beta-lactamases) keeb kwm.
YPuas cephalosporins cuam tshuam los ntawm beta-lactamase?
Qee hom kab mob tsim beta-lactamase enzymes, uas tshem tawm cov beta-lactam pawg hauv cov tshuaj tua kab mob, xws li cephalosporins, uas muaj lub nplhaib beta-lactam hauv lawv cov qauv. Ua li no, beta-lactamase enzyme inactivates cov tshuaj tua kab mobthiab dhau los ua cov tshuaj tua kab mob.
Cov tshuaj tua kab mob twg tiv taus ntau dua rau beta-lactamase?
Cov tshuaj tua kab mob tiv thaiv kab mob tau qhia tias cov tshuaj tua kab mob ua tau zoo tshaj plaws yog imipenem (96.4% raws li tus kab mob susceptibility) ua raws li ceftriaxone (58.3%) thiab gentamicin (54.8%). Cov tshuaj tiv thaiv siab tau pom nrog amoxicillin (92.8%), ampicillin (94%), thiab trimethoprim / sulfamethoxazole (85.7%).
YPuas yog cefazolin beta-lactamase resistant?
Qee cov tshuaj tua kab mob (xws li, cefazolin thiab cloxacillin) yog naturally resistant rau qee yam beta-lactamasesCov haujlwm ntawm beta-lactams: amoxicillin, ampicillin, piperacillin, thiab ticarcillin, tuaj yeem rov qab thiab nthuav dav los ntawm kev sib txuas nrog cov beta-lactamase inhibitor.
