Dimercaprol yog qhov zoo tshaj plaws thaum siv hauv 1 lossis 2 teev tom qab muaj tshuaj lom tam simCov tshuaj no yuav tsis zoo li kev kho tshuaj lom mus ntev (mob lom uas tau tshwm sim dhau los. lub sijhawm ntev). Qee zaum Dimercaprol tau muab rau ob peb hnub, nyob ntawm seb hom tshuaj lom raug kho.
Dab tsi yog qhov qhia rau kev siv Dimercaprol?
Dimercaprol yog siv rau kho arsenic / kub tshuaj lom, tshuaj lom mercury, thiab tshuaj lom lead. Dimercaprol yog siv off-label nyob rau hauv tsawg zaus los kho tus kab mob Wilson. Dimercaprol muaj nyob rau hauv cov npe sib txawv hauv qab no: BAL.
Dimercaprol tshuaj siv rau dab tsi?
Dimercaprol, los yog British anti-Lewisite (BAL), yog parenterally tswj hnyav hlau chelating tus neeg saib xyuas uas yog siv los kho arsenic, kub, tooj liab thiab mercury lom.
Dimercaprol yog dab tsi?
Mechanism of Action
Dimercaprol yog ib qho dithiol uas ua los ntawm kev tsim ib lub nplhaib tsib tus tswvcuab ruaj khov ntawm nws pawg sulfhydryl thiab qee cov hlau hnyav, yog li neutralizing nws toxicity thiab txhawb nqa nws qhov kev tshem tawm.
Dimercaprol ua li cas hauv tshuaj lom arsenic?
Arsenic thiab lwm yam hlau hnyav ua los ntawm tshuaj ua haujlwm nrog thiol residues uas nyob ib sab ntawm cov enzymes metabolic, tsim kom muaj chelate complex uas inhibits cuam tshuam enzyme txoj haujlwm. Dimercaprol sib tw nrog thiol pawg rau khi cov hlau ion, uas tom qab ntawd tawm hauv cov zis.
