Cov txheej txheem:
- Cov tshuaj twg yog metabolized los ntawm P450?
- Cyp450 enzyme system yog dab tsi?
- Cov tshuaj twg yog ib qho enzyme inducer ntawm cyp450?
- Lub luag haujlwm ntawm cytochrome P450 yog dab tsi?
Video: Puas sulfonamides siv cyp450 enzyme system?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Tshuaj-tshuaj tshuaj sib cuam tshuam ntawm tolbutamide thiab sulfonamides tau tshaj tawm. … Txawm hais tias cytochrome P450 (CYP) 2C8, 2C9, thiab 2C19 metabolized tolbutamide, lub ntsiab enzyme koom nrog yog CYP2C9 K(i) qhov tseem ceeb ntawm ntau sulfonamides tau piv ntawm tib neeg lub siab microsomes thiab recombinant CYP2C9..
Cov tshuaj twg yog metabolized los ntawm P450?
Ntawm cov tshuaj metabolized yog sedatives xws li midazolam, triazolam thiab diazepam, cov tshuaj tiv thaiv kab mob amitriptyline thiab imipramine, cov tshuaj tiv thaiv kab mob amiodarone, quinidine, propafenone thiab disopyramide, cov tshuaj tiv thaiv kab mob., astemizole thiab loratidine, calcium channel antagonists xws li diltiazem thiab …
Cyp450 enzyme system yog dab tsi?
Cytochromes P450 (CYPs) yog ib lub tsev ntawm cov enzymes uas muaj heme ua cofactor uas ua haujlwm li monooxygenasesHauv cov tsiaj nyeg, cov proteins no oxidize steroids, fatty acids, thiab xenobiotics, thiab yog tseem ceeb rau kev tshem tawm ntawm ntau lub tebchaw, nrog rau kev tsim cov tshuaj hormones thiab kev tawg.
Cov tshuaj twg yog ib qho enzyme inducer ntawm cyp450?
Phenobarbital yog lub zog cytochrome P450 enzyme inducer, ua rau muaj kev cuam tshuam nrog lwm yam tshuaj los ntawm kev ua kom lawv tshem tawm.
Lub luag haujlwm ntawm cytochrome P450 yog dab tsi?
Keeb Kwm: Cov cytochrome P450 (CYP) enzymes yog cov membrane-bound hemoproteins uas ua lub luag haujlwm tseem ceeb hauv kev tshem tawm ntawm xenobiotics, cellular metabolism thiab homeostasis Induction lossis inhibition ntawm CYP enzymes yog ib lub tswv yim tseem ceeb uas cuam tshuam txog kev siv tshuaj yeeb-tshuaj.
Pom zoo:
Puas siv tshuab ntaus ntawv puas tseem siv?
Lub tshuab tseem siv dav hauv thaj chaw hauv ntiaj teb xws li Is Nrias teb thiab Latin America, qhov hluav taws xob ntseeg tau qee zaum tsis lav. Olivetti, ib qho ntawm cov khoom siv tshuab ntaus ntawv kawg kawg, yog nyob hauv Brazil. … Cov tub ntxhais hluas Asmeskas siv tshuab ntaus ntawv ib yam nkaus-txawm tias lawv cov laj thawj feem ntau yog qhov zoo nkauj .
Puas siv phau ntawv ntse siv rau ntawm cov khoom siv promethean?
Koj tuaj yeem tsim cov haujlwm uas siv LAB thiab lawv yuav ua haujlwm zoo ib yam thaum siv lub rooj tsavxwm Promethean. … Raws li koj tab tom siv Phau Ntawv Teev Npe ntawm Promethean lub rooj tsavxwm, cov haujlwm LAB yuav ua haujlwm tau zoo thiab sib tham sib .
Vim li cas cov neeg siv khoom thiab cov khoom siv tau siv hauv c ++?
Lub hom phiaj ntawm kev siv getters thiab setters yog txhawm rau zais cov ntaub ntawv khaws cia thiab rov qab li casTxoj kev no, yog tias koj hloov tus cwj pwm, koj tsis tas yuav hloov tus lej. nyob rau hauv ib txhiab qhov chaw. Tab sis, yog tias koj tsis tas yuav hloov qhov kev siv, koj tau ua koj cov cai ntau dua thiab tau txais me ntsis los ntawm kev ua li ntawd .
Dab tsi yog sulfonamides inhibit?
Sulfonamides sib tw inhibit kev koom ua ke ntawm PABA rau hauv folic acid, yog li tiv thaiv kev sib txuas ntawm folic acid. Trimethoprim khi reversibly rau thiab inhibits dihyrofolate reductase, ib qho enzyme uas txo dihydrofolic acid rau tetrahydrofolic acid, txo folic acid synthesis .
Puas sulfonamides ua rau daim siab mob?
Cov sulfonamides yog paub zoo tias ua rau lub siab raug mob idiosyncratic Hepatotoxicity zoo li yog cov nyhuv hauv chav kawm, qhov zoo li txhua tus sulfonamides siv niaj hnub no tau txuas nrog tsawg, tab sis kev ntseeg siab ntawm tshuaj induced siab raug mob tshuaj induced siab raug mob Drug-induced siab raug mob (DILI) yog txhais raws li ib lub siab raug mob los ntawm ntau yam tshuaj, tshuaj ntsuab, los yog lwm yam xenobiotics, ua rau abnormality nyob rau hauv daim siab ntsu