Tshuaj-tshuaj tshuaj sib cuam tshuam ntawm tolbutamide thiab sulfonamides tau tshaj tawm. … Txawm hais tias cytochrome P450 (CYP) 2C8, 2C9, thiab 2C19 metabolized tolbutamide, lub ntsiab enzyme koom nrog yog CYP2C9 K(i) qhov tseem ceeb ntawm ntau sulfonamides tau piv ntawm tib neeg lub siab microsomes thiab recombinant CYP2C9..
Cov tshuaj twg yog metabolized los ntawm P450?
Ntawm cov tshuaj metabolized yog sedatives xws li midazolam, triazolam thiab diazepam, cov tshuaj tiv thaiv kab mob amitriptyline thiab imipramine, cov tshuaj tiv thaiv kab mob amiodarone, quinidine, propafenone thiab disopyramide, cov tshuaj tiv thaiv kab mob., astemizole thiab loratidine, calcium channel antagonists xws li diltiazem thiab …
Cyp450 enzyme system yog dab tsi?
Cytochromes P450 (CYPs) yog ib lub tsev ntawm cov enzymes uas muaj heme ua cofactor uas ua haujlwm li monooxygenasesHauv cov tsiaj nyeg, cov proteins no oxidize steroids, fatty acids, thiab xenobiotics, thiab yog tseem ceeb rau kev tshem tawm ntawm ntau lub tebchaw, nrog rau kev tsim cov tshuaj hormones thiab kev tawg.
Cov tshuaj twg yog ib qho enzyme inducer ntawm cyp450?
Phenobarbital yog lub zog cytochrome P450 enzyme inducer, ua rau muaj kev cuam tshuam nrog lwm yam tshuaj los ntawm kev ua kom lawv tshem tawm.
Lub luag haujlwm ntawm cytochrome P450 yog dab tsi?
Keeb Kwm: Cov cytochrome P450 (CYP) enzymes yog cov membrane-bound hemoproteins uas ua lub luag haujlwm tseem ceeb hauv kev tshem tawm ntawm xenobiotics, cellular metabolism thiab homeostasis Induction lossis inhibition ntawm CYP enzymes yog ib lub tswv yim tseem ceeb uas cuam tshuam txog kev siv tshuaj yeeb-tshuaj.
