Ntau qhov tshwj xeeb pyruvate carboxylase yog qhib los ntawm acetyl-CoA Vim tias acetyl-CoA yog ib qho tseem ceeb metabolite nyob rau hauv lub voj voog TCA uas tsim tawm ntau lub zog, thaum muaj ntau ntawm acetyl-CoA. yog cov kab mob siab siv pyruvate carboxylase rau channel pyruvate deb ntawm TCA voj voog.
Dab tsi txhawb nqa pyruvate carboxylase enzyme?
Y Pyruvate Carboxylase Deficiency. Pyruvate carboxylase (PC) yog biotin- thiab ATP-dependent mitochondrial enzyme uas catalyzes anaplerotic carboxylation ntawm pyruvate rau oxaloacetate, substrate rau gluconeogenesis. … PC xav tau
magnesium lossis manganese thiab acetyl-CoA los ua nws txoj haujlwm.
Yuav ua li cas nce pyruvate carboxylase kev ua haujlwm?
PC thiab metabolic adaptation
Nyob rau hauv cov xwm txheej ntawm kev noj zaub mov ntau dhau (kev noj zaub mov carbohydrate siab) (Daim duab 2A), PC qhia yog nce hauv β-cells rau txhim kho pyruvate kev caij tsheb kauj vab hauv kev teb rau cov qib qabzib ntev ntev [35].
Dab tsi ua kom pyruvate carboxylase hauv gluconeogenesis?
Pyruvate carboxylase catalyzes thawj kauj ruam rau gluconeogenesis thiab npaj tau zoo los tswj cov piam thaj hauv siab. Pyruvate carboxylase yog allosterically qhib los ntawm acetyl-CoA (18).
pyruvate carboxylase tswj li cas?
Kev ua haujlwm ntawm biotin-dependent enzyme pyruvate carboxylase los ntawm ntau cov kab mob yog tswj hwm los ntawm cov allosteric activator acetyl-CoA … etli enzyme, tsuas yog ob ntawm plaub subunits muaj cov allosteric activator khi rau lawv thiab tau kho kom zoo rau catalysis ntawm tag nrho cov tshuaj tiv thaiv.
