Pyruvate carboxylase (PC) yog biotin-bound mitochondrial enzyme uas catalyzes hloov pauv ntawm pyruvate mus rau oxaloacetate thaum muaj ntau acetyl CoA, ntxiv rau Krebs cycle intermediates hauv mitochondrialmatrix. PC koom nrog hauv gluconeogenesis, lipogenesis, thiab neurotransmitter synthesis.
Lub luag haujlwm ntawm pyruvate carboxylase yog dab tsi?
Pyruvate carboxylase (PC) yog biotin-muaj enzyme uas catalyses HCO 3 -- thiab MgATP -dependent carboxylation ntawm pyruvate los tsim oxaloacetate Qhov no yog ib qho tseem ceeb heev cov tshuaj tiv thaiv anaplerotic, ntxiv oxaloacetate tshem tawm ntawm lub voj voog Krebs rau ntau txoj hauv kev biochemical.
Vim li cas pyruvate carboxylase xav tau ATP?
Function. Thaum lub sij hawm gluconeogenesis, pyruvate carboxylase yog koom nrog hauv kev sib txuas ntawm phosphoenolpyruvate (PEP) los ntawm pyruvate. Pyruvate yog thawj zaug hloov los ntawm pyruvate carboxylase rau oxaloacetate (OAA) hauv mitochondrion xav tau hydrolysis ntawm ib molecule ntawm ATP.
Vim li cas pyruvate carboxylase qhib los ntawm acetyl CoA?
Ntau qhov tshwj xeeb pyruvate carboxylase yog qhib los ntawm acetyl-CoA. Vim hais tias acetyl- CoA yog ib qho tseem ceeb metabolite nyob rau hauv lub voj voog TCA uas tsim tau ntau lub zog, thaum cov concentrations ntawm acetyl-CoA yog cov kab mob siab siv pyruvate carboxylase rau channel pyruvate deb ntawm TCA cycle.
YPuas yog pyruvate dehydrogenase hauv mitochondria?
Nws tau pom tias pyruvate dehydrogenase enzyme pom nyob rau hauv mitochondria ntawm eukaryotic cells zoo ib yam li cov enzyme los ntawm Geobacillus stearothermophilus, uas yog hom kab mob gram-zoo.
