Adenylate cyclase deactivated li cas?

2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38

Qhov G-alpha-GTP complex tom qab ntawd khi rau adenylyl cyclase thiab ua rau kom muaj zog thiab tso tawm cAMP. … Lub deactivation ntawm lub active G-alpha-GTP complex yog ua tiav sai heev los ntawm GTP hydrolysis vim cov tshuaj tiv thaiv yog catalyzed los ntawm intrinsic enzymatic kev ua ntawm GTPase nyob rau hauv lub alpha subunit.

Kuv yuav ua li cas lov tes taw adenylyl cyclase?

Kev tsis ua haujlwm

1. cAMP phosphodiesterase hloov cAMP rau hauv AMP los ntawm kev rhuav tshem phosphodiester daim ntawv cog lus, tig los txo cov qib cAMP.
2. G_{i protein, uas yog G protein uas inhibits adenylyl cyclase, txo cAMP qib.}

Dab tsi tuaj yeem nres txoj kev adenylyl cyclase?

Txhua hom kev paub ntawm adenylyl cyclase yog inhibited los ntawm P-site inhibitors, uas yog adenosine analogues uas tej zaum ua rau ntawm qhov chaw catalytic ntawm enzyme. Cov qauv saum toj kawg nkaus ntawm adenylyl cyclases zoo ib yam li cov membrane thauj thiab ion channels.

Dab tsi ntawm cov hauv qab no cuam tshuam cov haujlwm ntawm adenylyl cyclase?

Kev khi ntawm kev txhawb nqa G alpha (G_s) txhim kho kev ua si thaum khi ntawm ib qho inhibitory G alpha (G_i) inhibited cyclase kev ua. … Tsis tas li ntawd, thaum epinephrine khi rau alpha-2 adrenergic receptors, adenylyl cyclase kev ua haujlwm yog inhibited, vim hais tias tus receptor yog txuas mus rau ntawm G_{i, inhibitory G protein.}

G proteins inhibit adenylyl cyclase li cas?

Thaum lub heterotrimeric G protein yog qhib los ntawm GPCR, lub trimer dissociates, ua rau ib tug α subunit thiab βγ dimer [2]. Activated Gα subunits thauj cov teeb liab los ntawm daim nyias nyias mus rau lwm thaj chaw ntawm lub xov tooj ntawm tes los ntawm kev txhawb los yog inhibiting cov kev cuam tshuam ntawm protein-protein kev sib cuam tshuam