Thaum adenylyl cyclase tau qhib, nws catalyses hloov pauv ntawm ATP rau cyclic AMP, uas ua rau muaj kev nce ntxiv hauv cov qib ntawm cov cyclic AMP.
Thaum adenylyl cyclase tau qhib ua dab tsi molecules lub signaling cascade?
Thaum ua haujlwm, adenylyl cyclase hloov pauv ntau ntawm ATP molecules rau hauv cov cim qhia, hu ua cyclic AMP (cAMP). Vim tias cAMP nqa cov lus ntawm thawj tus tub txib (epinephrine) mus rau hauv lub cell, cAMP raug xa mus ua tus xa xov thib ob.
Puas adenylyl cyclase nce cAMP?
Keeb Kwm / Lub Hom Phiaj: Kev Teeb Meem ntawm G s protein-coupled receptors (GsPCRs) yog ua tiav los ntawm kev txhawb nqa ntawm adenylyl cyclase, ua rau nce ntawm intracellular cAMP concentration., ua kom cov intracellular cAMP effectors protein kinase A (PKA) thiab Epac, thiab efflux ntawm cAMP, cov haujlwm uas tseem yog …
Dab tsi yog adenylate cyclase lub luag haujlwm rau?
Adenylate cyclase yog cov protein ntau tshaj plaws uas cuam tshuam thiab ua lub luag haujlwm rau hloov ATP rau tus xa xov thib ob cAMP (p. 69). … Ca2+ hauv cell ces khi rau Ca2+-binding protein calmodulin (piv txwv li cov leeg nqaij) lossis troponin (piv txwv li cov leeg pob txha) thiab qhov nyuaj no hloov pauv kev ua haujlwm ntawm tes.
Dab tsi ua kom lub enzyme adenylate cyclase?
Cyclic AMP yog ib qho tseem ceeb molecule nyob rau hauv eukaryotic signal transduction, ib tug thiaj li hu ua thib ob tub txib. Adenylyl cyclases feem ntau yog qhib los yog inhibited los ntawm G proteins, uas yog txuas rau daim nyias nyias receptors thiab yog li tuaj yeem teb rau hormonal lossis lwm yam stimuli.