Tshuaj lom nrog rotenone tsis tshua muaj tshwm sim tab sis muaj peev xwm ua rau tuag taus vim tus neeg sawv cev no inhibits cov kab mob mitochondrial ua pa Kev tshawb fawb hauv vitro cell tau pom tias rotenone-induced toxicity yog txo los ntawm kev siv N. -acetylcysteine, antioxidants thiab potassium channel openers.
Vim li cas rotenone lom rau tib neeg?
Lub tshuab ntawm rotenone toxicity yog kho kom haum dhau ntawm qhov inhibition ntawm mitochondrial respiratory chain complex I. Qhov inhibition ntawm complex I los ntawm rotenone induces mitochondrial ROS ntau lawm thiab programmed cell tuag (Li li al., 2003).
rotenone tua li cas?
Rotenone tua by inhibiting cellular respiration in mitochondria, uas ua rau txo cellular uptake oxygen. Nws cuam tshuam rau feem ntau cov tsiaj ua pa hauv dej xws li ntses, amphibians thiab kab.
Puas rotenone tuag rau tib neeg?
Nws yog ib qho mob me me rau tib neeg thiab lwm yam tsiaj txhu, tab sis tsis tshua muaj tshuaj lom rau kab thiab dej hauv dej, suav nrog ntses. … Tib neeg tuag los ntawm kev lom rotenone tsis tshua muaj vim nws qhov ua rau ntuav. Kev txhob txwm noj rotenone tuaj yeem ua rau tuag taus.
Ntau npaum li cas rotenone tuag taus?
Cov koob tshuaj tuag ntawm rotenone yog 300–500 mg / kg rau tus neeg laus, 143 mg / kg rau menyuam yaus thiab 132 mg / kg rau nas (2, 10, 16–18). Rotenone raug cais ua tus neeg sawv cev hauv chav kawm II (muaj kev phom sij txaus ntshai) los ntawm WHO (2, 19). Nws sai sai decomposes hauv dej, huab cua thiab hnub ci.
