Rotenone cuam tshuam aerobic cellular ua pa los ntawm thaiv kev thauj khoom hluav taws xob hauv mitochondria los ntawm inhibition ntawm enzyme NADH ubiquitone reductase, uas tiv thaiv kom muaj oxygen rau cellular respiration.
rotenone cuam tshuam li cas rau cov saw hlau thauj electron?
Rotenone, tshuaj tua kab mob botanical, yog ib qho inhibitor ntawm ib qho ntawm cov enzymes ntawm Complex I ntawm cov saw hlau thauj electron. Nyob rau hauv lub xub ntiag ntawm cov tshuaj tua kab no, electrons los ntawm NADH tsis tuaj yeem nkag mus rau cov saw hlau thauj electron, ua rau qhov tsis muaj peev xwm tsim ATP los ntawm oxidation ntawm NADH
Lub luag haujlwm ntawm rotenone yog dab tsi?
Rotenone (Fig.50.1A) yog ib qho khoom siv ntuj tsim, siv los ua tshuaj tua kab thiab tshuaj tua kabRotenone yog ib qho tshwm sim ntawm ketone, muab los ntawm cov hauv paus hniav ntawm Lonchocarpus hom (Uversky, 2004). Nws yog ib qho tshuaj tua kab uas nquag siv thiab tseem siv hauv pas dej thiab cov pas dej kom tua ntses uas pom tias yog kab tsuag.
Yuav ua li cas rotenone inhibit ATP synthesis?
Rotenone ua raws li qhov muaj zog inhibitor ntawm complex I ntawm mitochondrial respiratory saw (MRC). Cov txheej txheem ntawm kev ua (MOA) suav nrog txwv tsis pub hloov pauv hluav taws xob los ntawm cov chaw hlau-sulfur hauv txoj haujlwm kuv mus rau ubiquinone , ua rau muaj kev cuam tshuam ntawm oxidative phosphorylation nrog txwv kev sib txuas ntawm ATP 2
rotenone cuam tshuam li cas rau kev siv oxygen?
Rotenone inhibits Complex I, tab sis lub xub ntiag ntawm succinate yuav ua rau cov hluav taws xob nkag mus rau ntawm Complex II. (h) Oxygen noj tsis tu ncua vim Complex IV yog inhibited thiab tag nrho cov saw rov qab.
