Curare cuam tshuam rau qhov stimulus (EPSP) uas ib txwm ua rau qhov pib ntawm cov leeg nqaij muaj peev xwm Tus tsiaj uas raug tshuaj lom nrog curare yuav asphyxiate vim tias cov txheej txheem ntawm neuromuscular kis mus rau neuromuscular kis tau tus mob neuromuscular hlws ris (los yog myoneural junction) yog tshuaj synapse ntawm lub cev muaj zog neuron thiab cov leeg nqaijNws tso cai rau lub cev muaj zog neuron xa cov teeb liab mus rau cov leeg nqaij, ua rau cov leeg mob. Cov leeg yuav tsum tau innervation rau kev ua haujlwm-thiab txawm tias tsuas yog tswj cov leeg nqaij, tsis txhob atrophy. https://en.wikipedia.org › wiki › Neuromuscular_junction
Neuromuscular junction - Wikipedia
ntawm cov leeg ua pa yog thaiv. Nquag, qhov loj ntawm cov phaj kawg muaj peev xwm loj heev.
Qhov txiaj ntsig ntawm curare yog dab tsi?
Curare ua raws li tus neeg saib xyuas neuromuscular thaiv los ntawm kev khi rau acetylcholine receptor (AChR) ntawm qhov sib txuas neuromuscular thiab tiv thaiv cov paj hlwb los ntawm kev ua kom cov leeg pob txha (Bowman, 2006).
curare cuam tshuam dab tsi ntawm cov leeg nqaij daim ntawv xeem?
Curare ua rau cov acetylcholine receptors ntawm lub cev lub cev ntawm cov leeg. Nws ua li ntawd los ntawm kev thaiv cov nicotinic acetylcholine receptors.
Dab tsi ua rau cov leeg nqaij muaj peev xwm ua tau?
Ua kom nAChR ua rau kev nkag mus ntawm cations (sodium thiab calcium) uas ua rau depolarization ntawm cov leeg nqaij daim nyias nyias. Qhov no depolarization nyob rau hauv lem activates ib tug siab ceev ntawm voltage-gated sodium raws ntawm cov leeg nqaij daim nyias nyias, eliciting muaj peev xwm ua.
Dab tsi yog qhov txawv ntawm qhov kawg phaj muaj peev xwm thiab qhov ua tau zoo?
End-phaj peev xwm (EPP), tshuaj lom neeg hloov pauv hauv lub peev xwm hluav taws xob ntawm lub tshuab kawg phaj, feem ntawm cov leeg-hlwb daim nyias nyias uas nyob sab nraud ntawm lub davhlau ya nyob twg ntawm cov hlab ntsha ntawm cov hlab ntsha neuromuscular.… Cov peev xwm ua tau yuav ua rau cov leeg nqaij cell kom cog lus
