Mutagens yog cov tshuaj uas ua rau DNA puas tsuaj DNA DNA puas yog txhais tau tias yog kev hloov pauv hauv DNA qauv uas muaj peev xwm ua rau cov cellular raug mob thiab txo cov kev muaj peev xwm los yog kev tsim tawm ntawm cov kab mob(Kaufmann thiab Paules, 1996). https://www.sciencedirect.com › topics › dna-kev puas tsuaj
DNA Kev puas tsuaj - kev saib xyuas | ScienceDirect Topics
thiab tuaj yeem, nyob ntawm lub peev xwm ntawm lub cev los kho qhov kev puas tsuaj, ua rau muaj kev hloov pauv mus tas li (kev hloov pauv) hauv DNA ntu. Tab sis cov neeg ua haujlwm uas ua rau DNA puas tuaj yeem ua rau deoxynucleoside triphosphates (dNTPs), uas yog siv los ntawm DNA polymerases los hloov DNA.
Vim li cas kev hloov pauv tseem ceeb?
Qhov kawg ntawm txhua qhov kev hloov pauv caj ces yog kev hloov pauv. Kev hloov pauv yog qhov tseem ceeb raws li thawj kauj ruam ntawm kev hloov pauv vim tias nws tsim cov DNA tshiab rau ib lub noob, tsim cov allele tshiabKev sib xyaw ua ke kuj tuaj yeem tsim cov DNA tshiab (ib qho allele tshiab) rau ib qho Cov noob tshwj xeeb los ntawm kev sib xyaw ua ke ntawm intragenic.
Yuav ua li cas mutagen muaj txiaj ntsig?
Cov mutagen tsim mutations hauv DNA, thiab kev hloov pauv tsis zoo tuaj yeem ua rau muaj qhov tsis zoo, ua tsis taus lossis tsis ua haujlwm rau qee cov noob, thiab kev sib txuam ntawm kev hloov pauv tuaj yeem ua rau mob qog noj ntshav. Yog li ntawd, Mutagens kuj tseem yog cov carcinogens.
Yuav ua li cas mutagen ua rau DNA?
Ib mutagen yog ib yam tshuaj los yog lub cev tshwm sim, xws li ionizing hluav taws xob, uas promotes yuam kev hauv DNA replication. Kev kis mus rau mutagen tuaj yeem tsim cov kev hloov DNA uas ua rau lossis ua rau muaj kab mob xws li mob qog noj ntshav.
Yuav ua li cas mutagen ua rau kev hloov pauv?
Mutagens ua rau muaj kev hloov pauv los ntawm yam tsawg kawg peb yam sib txawv. Lawv tuaj yeem hloov lub hauv paus hauv DNA, hloov lub hauv paus kom nws tshwj xeeb mispairs nrog lwm lub hauv paus, lossis puas lub hauv paus kom nws tsis tuaj yeem ua khub nrog ib lub hauv paus nyob rau hauv ib txwm muaj.