Ribonuclease A Ribonuclease A Bovine pancreatic ribonuclease, kuj feem ntau hu ua bovine pancreatic ribonuclease A lossis yooj yim RNase A, yog pancreatic ribonuclease enzyme uas cleaves ib leeg-stranded RNAatic Bovine ribonuclease yog ib qho ntawm cov qauv qauv ntawm cov protein science. https://en.wikipedia.org › Bovine_pancreatic_ribonuclease
Bovine pancreatic ribonuclease - Wikipedia
yog lub plab zom mov secreted los ntawm pancreas uas tshwj xeeb "digests" lossis hydrolyzes RNA (tab sis tsis yog DNA) polymers los ntawm endonuclease cleavage ntawm phosphodiester bonds tsim cov kev sib txuas ntawm cov nyob ib sab. ribonucleotide residues nyob rau hauv cov molecules.
Vim li cas hlwb thiaj muaj ribonuclease?
Ribonucleases (RNases) ua si lub luag haujlwm tseem ceeb hauv txhua yam ntawm RNA metabolism, tab sis lawv kuj tuaj yeem ua rau cov enzymes puas tsuaj uas yuav tsum tau tswj kom tsis txhob plam kev puas tsuaj ntawm RNA molecules.. Raws li qhov tshwm sim, cov hlwb tau hloov kho ntau lub tswv yim los tiv thaiv RNAs tawm tsam RNase kev ua.
RNase nyob qhov twg?
RNA ib feem ntawm RNase P yog pom nyob rau hauv cov cytosolic feem ntawm cov hlwb overexpressing no RNA, thaum lub overexpressed RNase P protein sediments nrog cov membrane feem; qhov no qhia tias RNase P protein anchors RNA catalytic moiety ntawm enzyme mus rau ib qho chaw loj.
Thaum twg ribonuclease A nrhiav tau?
Pancreatic ribonuclease tau piav qhia thawj zaug hauv 1920 los ntawm American biochemist W alter Jones (1865-1935), uas qhia tias nws tuaj yeem zom cov poov xab RNA. Nws tau raug ntxuav ib nrab xyoo 1938 los ntawm American microbiologist René Jules Dubos (1901-1982) thiab cais tawm hauv crystalline daim ntawv ob xyoos tom qab los ntawm M. Kunitz.
Dab tsi yog txoj haujlwm ntawm Ribonucleases?
Ribonucleases (RNases) yog cov neeg tseem ceeb ntawm kev tiv thaiv tus tswv tsev thiab pab tswj cov ntaub so ntswg homeostasis thiab lub cev tsis muaj dej. Secreted raws li ib tug ntau haiv neeg ntawm cellular raug mob, lawv kho cov txheej txheem signaling, thiab tau muab faib ua alarmins (1).
