Lactate [CH3CH(OH)COO−] ua cov khoom siv raw rau kev tsim dua tshiab ntawm bicarbonate (HCO3−). Lub siab metabolizes lactate rau glycogen uas tom qab ntawd hloov mus rau carbon dioxide thiab dej los ntawm oxidative metabolism. Qhov no, nyob rau hauv lem, generates bicarbonate.
Lactate ua rau metabolic acidosis li cas?
Lactic acidosis tshwm sim thaum lactic acid ntau tshaj lactic acid clearance. Qhov nce hauv lactate ntau lawm feem ntau yog tshwm sim los ntawm tsis txaus cov ntaub so ntswg oxygenation, los ntawm kev xa cov pa oxygen tsawg lossis qhov tsis zoo hauv kev siv mitochondrial oxygen. (Saib "Txoj kev mus rau cov neeg laus nrog metabolic acidosis".)
YLactate metabolized rau hauv dab tsi?
Lub lactate diffuses tawm ntawm lub hlwb thiab hloov mus rau pyruvate thiab ces yog aerobically metabolized rau carbon dioxide thiab ATP Lub plawv, siab, thiab ob lub raum siv lactate li no. Xwb, lub siab thiab lub raum cov ntaub so ntswg tuaj yeem siv lactate los tsim cov piam thaj los ntawm lwm txoj hauv kev hu ua gluconeogenesis.
Puas muaj bicarbonate hauv lactated Ringer?
Piv txwv li, LR muaj SID ntawm 28 mM. Txawm hais tias nws tsis muaj bicarbonate hauv nws, nws muaj 28 mM ntawm sodium lactate uas tau hloov pauv sai sai rau hauv sodium bicarbonate los ntawm lub siab. Yog li muab LR muaj txiaj ntsig zoo ib yam ntawm pH li infusing cov kua dej nrog 28 mM sodium bicarbonate ntxiv.
Lactic acidosis ua li cas?
Lactic acidosis yog hais txog lactic acid tsim nyob rau hauv cov hlab ntsha. Lactic acid yog tsim thaum oxygen qib qis hauv cov hlwb hauv thaj chaw ntawm lub cev uas cov metabolism ua haujlwm.
