Vinca alkaloids yog muaj peev xwm vesicants [80–82] thiab kev siv tshuaj tsis raug cai tuaj yeem ua rau cov nqaij mos mob hnyav.
YPuas yog vinca alkaloids cytotoxic?
Lawv tau siv los kho ntshav qab zib, ntshav siab thiab tau siv los ua tshuaj tua kab mob thiab tiv thaiv qog noj ntshav. Cov vinca alkaloids muaj cytotoxic teebmeemuas tuaj yeem ntes kev faib cov hlwb thiab ua rau cov cell tuag. Muaj plaub qhov loj vinca alkaloids hauv kev kho mob: VBL, VRL, VCR thiab VDS.
Vinca alkaloids ua dab tsi?
Vinca alkaloids yog siv hauv tshuaj kho mob qog noj ntshav Lawv yog cov chav kawm ntawm lub voj voog ntawm tes-cov tshuaj cytotoxic tshwj xeeb uas ua haujlwm los ntawm inhibiting lub peev xwm ntawm cov qog nqaij hlav qog noj ntshav: Ua raws li tubulin, Lawv tiv thaiv nws los ntawm kev tsim mus rau hauv microtubules, ib qho tseem ceeb tivthaiv rau cellular faib.
Dab tsi yog tshuaj vinca alkaloids?
21.2.
Vinca alkaloids suav nrog vinblastine, vincristine, vindesine, thiab vinorelbinekeeb kwm los ntawm Catharanthus roseus (Apocynaceae). Lawv yog cov paub zoo hauv kev kho mob cytotoxic tshuaj inhibiting lub peev xwm ntawm cov qog nqaij hlav qog nqaij hlav [17].
YPuas yog vinca alkaloids DNA khi?
Kev tshawb fawb Fluorescence ntawm indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine thiab catharanthine tau pom tias DNA khi muaj peev xwm ntawm cov molecules. Kev khi hom ntawm cov molecules hauv qhov me me ntawm DNA tsis yog tshwj xeeb.
