Daim ntawv ubiquitous (ALAS1) yog qhia nyob rau hauv tag nrho cov ntaub so ntswg, nrog rau lub siab Daim ntawv erythroid-specific daim ntawv (ALAS2) tsuas yog qhia nyob rau hauv erythroid hlwb (Cox li al., 1990; Cotter et al., 1992). Txawm hais tias heme yog synthesized nyob rau hauv tag nrho cov hlwb, kwv yees li 85% yog tsim nyob rau hauv cov pob txha pob txha, thiab feem ntau ntawm cov seem nyob rau hauv lub siab.
Protoporphyrin tsim nyob qhov twg?
Ob kauj ruam oxidation catalyzed los ntawm CP oxidase thiab protoporphyrinogen oxidase (PPOX) ua rau kev tsim ntawm protoporphyrin IX hauv lub puab mitochondria membrane ntsib lub matrix.
porphyrins pom nyob qhov twg?
Porphyrins yog ubiquitous nyob rau hauv biological systems. Lawv yog cov chaw ua haujlwm hauv hemoglobin thiab chlorophyll. Lawv kuj yog ib feem ntawm cytochrome P-450 enzyme systems uas tsis tsuas yog tam sim no nyob rau hauv lub siabntawm cov kab mob siab dua tab sis kuj nyob rau hauv cov kab mob microbial.
Hmoob nyob qhov twg?
Heme synthesis tshwm sim ib feem hauv mitochondria thiab ib nrab hauv cytoplasm txheej txheem pib hauv mitochondria vim tias ib qho ntawm cov precursors tsuas pom muaj nyob ntawd. Txij li cov tshuaj tiv thaiv no tau tswj hwm ib feem los ntawm qhov concentration ntawm heme, cov kauj ruam kawg (uas ua rau heme) kuj yog mitochondrial.
YPuas Protoporphyrin zoo ib yam li porphyrin?
Qhov sib txawv tseem ceeb ntawm porphyrin thiab protoporphyrin yog tias porphyrin yog ib pawg ntawm cov tshuaj tsw qab uas muaj plaub qhov hloov pauv pyrrole subunits interconnected rau ib leeg, whereas protoporphyrin yog derivative ntawm porphyrin uas muaj propionic acid pawg.
