Kev poob ntawm kev sib haum xeeb entropy yog ib qho kev koom tes loj hauv cov thermodynamics ntawm cov protein folding Txawm li cas los xij, kev txiav txim siab tseeb ntawm qhov ntau tau ua pov thawj nyuaj. Peb xam qhov kev poob no siv cov kev sim molecular dynamic simulations ntawm ob qho tib si cov protein thiab ib lub xeev muaj tseeb denatured ensemble.
Dab tsi yog conformational entropy protein?
Conformational entropy is the entropy txuam nrog tus naj npawb ntawm conformations ntawm ib molecule. … Nyob rau hauv cov proteins, qaum dihedral ces kaum thiab sab saw rotamers feem ntau yog siv raws li tsis, thiab nyob rau hauv RNA lub hauv paus khub qauv yuav siv tau.
Qhov twg muaj ntau dua conformational entropy ib folded protein los yog unfolded ib?
Qhov kev sib koom ua ke ntawm cov saw hlau polypeptide yog qhov loj dua rau unfolded xeev piv rau lub xeev ntau dua qub uas muaj ntau qhov chaw txwv tsis pub muaj. Yog li ntawd, qhov kev pab cuam no ruaj khov rau lub xeev unfolded (ΔSconf > 0).
Yuav ua li cas txiav txim siab cov protein sib haum thiab qhov teeb meem cuam tshuam nrog cov protein folding yog dab tsi?
Cov qauv tseem ceeb ntawm cov protein, nws cov kab sib txuas amino-acid, txiav txim siab nws qhov kev sib haum xeeb. Cov amino acid residues tshwj xeeb thiab lawv txoj hauj lwm hauv cov saw hlau polypeptide yog qhov kev txiav txim siab rau qhov twg ntawm cov protein folds ze ua ke thiab tsim nws cov qauv peb sab.
Yam dab tsi cuam tshuam rau qhov folding ntawm cov protein?
Protein folding yog txheej txheem rhiab heev uas cuam tshuam los ntawm ntau yam sab nraud suav nrog hluav taws xob thiab hlau nplaum, qhov kub thiab txias, pH, tshuaj, qhov chaw txwv thiab molecular crowdingCov xwm txheej no cuam tshuam rau lub peev xwm ntawm Proteins txhawm rau txhawm rau hauv lawv cov ntawv ua haujlwm raug.
