Txoj hauv kev tseem ceeb ntawm kev tshem tawm yog raum tso tawm ntawm digoxin, uas yog sib raug zoo nrog cov glomerular pom tus nqi. Tsis tas li ntawd, qee qhov tubular secretion thiab tej zaum tubular reabsorption tshwm sim. Yuav luag tag nrho cov digoxin nyob rau hauv cov zis yog tawm tsis hloov, nrog ib feem me me raws li active metabolites.
Puas yog digoxin tshem tawm ntawm daim siab?
Nyob rau hauv xaus, hydrolysis ntawm digitoxin yog hloov pauv hauv daim siab cirrhosis, uas yog qhov txo qis hauv lub raum tshem tawm thiab tso zis rov qab ntawm digitoxigenin-mono-digitoxoside thiab digitoxigenin tau pom nyob rau hauv kev kawm tam sim no.
Dogoxin tawg li cas?
Nyob hauv lub cev, lub ntsiab lus tseem ceeb Digoxin (daim duab saum toj no) tau tawg (tawg ntawm glycosidic bonds) rau Digitoxin thiab qab zib. Cov digitoxin txhawb lub plawv, ua kom lub plawv dhia nrawm.
Dab tsi enzyme metabolizes digoxin?
Nws yog feem ntau metabolized los ntawm the CYP2C19 enzyme, ib tug tswv cuab ntawm pawg P450 sib xyaw ua haujlwm oxidase, txawm hais tias ib qho me me ntawm cov metabolism yog los ntawm CYP3A4, lwm P450 enzyme. Digoxin feem ntau metabolized sab nraum P450 system, tab sis txoj kev me me ntawm cov metabolism yog los ntawm CYP3A4.
CYP2C19 inhibitors yog dab tsi?
CYP2C19 catalyzes cov metabolism hauv ntau cov tshuaj, suav nrog cov tshuaj tiv thaiv proton twj tso kua mis (PPIs) (piv txwv li, omeprazole, lansoprazole, pantoprazole), antidepressants (piv txwv li, citalopram thiab amitriptyline), antiplatelet tshuaj (piv txwv li, clopidogrel), tshuaj tua kab mob (xws li, voriconazole), thiab tshuaj tiv thaiv kab mob (xws li, cyclophosphamide).
