Paracetamol yog metabolised ntau hauv daim siabthiab tawm hauv cov zis feem ntau yog glucuronide thiab sulfate conjugates. Tsawg dua 5% raug tshem tawm tsis hloov pauv. Cov metabolites ntawm paracetamol suav nrog me me hydroxylated intermediate uas muaj hepatotoxic kev ua haujlwm.
Paracetamol metabolized li cas?
Paracetamol yog metabolized feem ntau hauv daim siab (Daim duab 1) by enzymes ntawm theem I thiab II Phase I cov tshuaj tiv thaiv rau paracetamol yuav tshwm sim los ntawm oxidation, txo, thiab hydrolysis: Nws tshwm sim. nyob rau hauv polar metabolites ntawm cov tshuaj qub thiab ua rau kom ua kom lossis inactivation ntawm cov tshuaj.
txoj hauv kev tseem ceeb ntawm paracetamol metabolism yog dab tsi?
Glucuronidation yog txoj hauv kev tseem ceeb ntawm acetaminophen metabolism, ua raws li sulfation thiab ib qho me me los ntawm txoj kev oxidation.
tshuaj tiv thaiv rau paracetamol yog dab tsi?
Intravenous acetylcysteine yog cov tshuaj tua kab mob los kho paracetamol overdose thiab zoo li 100% zoo tiv thaiv daim siab puas thaum muab hauv 8 teev tom qab noj ntau dhau.
Paracetamol hloov mus rau paracetamol glucuronide li cas?
UDP-Glucuronyl transferases conjugate 52%–57% paracetamol ua paracetamol glucuronide thiab hepatic sulfotransferases conjugate 30%–44% paracetamol ua paracetamol sulfate, tsis muaj tshuaj lom neeg conjugate, thiab tom qab ntawd tawm los ntawm cov zis.
