Cov txheej txheem:
- Paracetamol metabolized li cas?
- txoj hauv kev tseem ceeb ntawm paracetamol metabolism yog dab tsi?
- tshuaj tiv thaiv rau paracetamol yog dab tsi?
- Paracetamol hloov mus rau paracetamol glucuronide li cas?
Video: Paracetamol metabolised li cas?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Paracetamol yog metabolised ntau hauv daim siabthiab tawm hauv cov zis feem ntau yog glucuronide thiab sulfate conjugates. Tsawg dua 5% raug tshem tawm tsis hloov pauv. Cov metabolites ntawm paracetamol suav nrog me me hydroxylated intermediate uas muaj hepatotoxic kev ua haujlwm.
Paracetamol metabolized li cas?
Paracetamol yog metabolized feem ntau hauv daim siab (Daim duab 1) by enzymes ntawm theem I thiab II Phase I cov tshuaj tiv thaiv rau paracetamol yuav tshwm sim los ntawm oxidation, txo, thiab hydrolysis: Nws tshwm sim. nyob rau hauv polar metabolites ntawm cov tshuaj qub thiab ua rau kom ua kom lossis inactivation ntawm cov tshuaj.
txoj hauv kev tseem ceeb ntawm paracetamol metabolism yog dab tsi?
Glucuronidation yog txoj hauv kev tseem ceeb ntawm acetaminophen metabolism, ua raws li sulfation thiab ib qho me me los ntawm txoj kev oxidation.
tshuaj tiv thaiv rau paracetamol yog dab tsi?
Intravenous acetylcysteine yog cov tshuaj tua kab mob los kho paracetamol overdose thiab zoo li 100% zoo tiv thaiv daim siab puas thaum muab hauv 8 teev tom qab noj ntau dhau.
Paracetamol hloov mus rau paracetamol glucuronide li cas?
UDP-Glucuronyl transferases conjugate 52%–57% paracetamol ua paracetamol glucuronide thiab hepatic sulfotransferases conjugate 30%–44% paracetamol ua paracetamol sulfate, tsis muaj tshuaj lom neeg conjugate, thiab tom qab ntawd tawm los ntawm cov zis.
Pom zoo:
Puas yog crocin thiab paracetamol tib yam?
Crocin yog lub npe khoom tiag tiag yog a paracetamol (acetaminophen kom meej). Crocin ntsiav tshuaj tuaj yeem muaj zog sib txawv (325mg, 500mg, 650mg), thiab feem ntau nws yog ib qho mob me me tab sis zoo tshuaj tua kab mob (cov tshuaj uas tau muab coj los ua rau peb kub taub hau) .
Puas yog paracetamol muaj cov tshuaj tua kab mob?
Paracetamol yog ib qho zoo- paub tshuaj tiv thaiv kab mob thiab tshuaj tua kab mobmuaj ntau xyoo rau kev tswj qhov ncauj vim qhov kev txhaj tshuaj tau raug cuam tshuam los ntawm dej insolubility . Puas yog paracetamol muaj tshuaj tua kab mob?
Thaum cawv yog metabolised?
Feem ntau cawv yog tawg, lossis metabolised, los ntawm ib qho enzyme hauv koj lub siab hlwb hu ua cawv dehydrogenase (ADH). ADH rhuav tshem cawv rau hauv acetaldehyde, thiab tom qab ntawd lwm enzyme, aldehyde dehydrogenase (ALDH), sai sai acetaldehyde rau hauv acetate .
Dab tsi yog metabolised hauv siab?
Lub siab ua lub luag haujlwm tseem ceeb hauv txhua yam txheej txheem metabolic hauv lub cev. Hauv cov metabolism hauv rog, lub siab lub hlwb zom cov rog thiab tsim lub zog. Lawv kuj tsim txog 800 mus rau 1,000 ml ntawm cov kua tsib ib hnub. … Lub siab hlwb hloov ammonia mus rau ib yam khoom uas muaj tshuaj lom tsawg heev hu ua urea, uas tso rau hauv cov ntshav .
Digoxin metabolised nyob qhov twg?
Txoj hauv kev tseem ceeb ntawm kev tshem tawm yog raum tso tawm ntawm digoxin, uas yog sib raug zoo nrog cov glomerular pom tus nqi. Tsis tas li ntawd, qee qhov tubular secretion thiab tej zaum tubular reabsorption tshwm sim. Yuav luag tag nrho cov digoxin nyob rau hauv cov zis yog tawm tsis hloov, nrog ib feem me me raws li active metabolites .
