Protein kinase A (PKA) yog qhib los ntawm kev khi ntawm cyclic AMP (cAMP), uas ua rau nws mus dhau qhov kev hloov pauv. Raws li tau hais dhau los, PKA tom qab ntawd mus rau phosphoylate lwm cov proteins hauv phosphorylation cascade (uas yuav tsum tau ATP hydrolysis).
Lub luag haujlwm ntawm cov protein kinase A yog dab tsi?
Zoo li lwm cov protein kinases, protein kinase A (tseem hu ua as lub cyclic AMP-dependent protein kinase lossis A kinase) yog ib qho enzyme uas covalently decorates proteins nrog phosphate pawg. … Qhov enzyme no ua haujlwm ua qhov kawg nkaus rau ntau yam tshuaj hormones uas ua haujlwm los ntawm kev ua haujlwm ntawm AMP kev taw qhia.
Kinases ua haujlwm li cas?
Kev ua haujlwm yog kho los ntawm kev khi ntawm cyclic AMP rau cov tswj hwm subunits, uas ua rau tso tawm cov catalytic subunits.cAPK feem ntau yog cov protein cytoplasmic, tab sis thaum ua kom nws tuaj yeem txav mus rau hauv lub nucleus, qhov chaw nws phosphorylates cov protein tseem ceeb rau kev tswj cov noob. Domain txav hauv cov protein kinases.
Tus tub txib thib ob dab tsi ua rau cov protein kinase A?
G protein dissociates thiab ib lub subunit cuam tshuam nrog thiab ua kom muaj enzyme - adenylate cyclase- uas hloov ATP rau hauv tus xa xov thib ob - cyclic AMP (cAMP) - hauv cell. cAMP activates protein kinase A (PKA) uas phosphorylates proteins ntawm cov Ser lossis Thr sab chains.
Yuav ua li cas cov protein ua kom qhib tau?
Lub enzyme yog qhib los ntawm cAMP, uas khi rau cov kev tswj hwm subunits thiab induces ib tug conformational hloov ua rau dissociation ntawm complex; cov dawb catalytic subunits yog ces enzymatically active protein kinases.
