a Kev ua kom tiav ua rau muaj kev tsim ntawm lub membrane nres complex(MAC lossis C5b-9; xiav) uas tua cov kab mob Gram-negative (txiv kab ntxwv) sai sai yam tsis muaj kev tiv thaiv kab mob. hlwb. Cov kab mob Gram-positive tiv taus MAC.
Yuav ua li cas thaum ua kom cov protein ntau ntxiv?
Qhov kawg tshwm sim ntawm qhov kev ua kom sib ntxiv no lossis ua kom tiav kev txhim kho cascade yog stimulation ntawm phagocytes kom tshem tawm cov khoom txawv teb chaws thiab puas, o kom nyiam phagocytes ntxiv, thiab ua kom cov cell-tua. membrane nres complex.
Yuav ua li cas ntxiv cov proteins tua cov kab mob?
Cov kab mob kuj tseem raug tua los ntawm phagocytes. Cov kab mob tiv thaiv kab mob zoo li cov kab mob hnyav (xws li ntxiv) thiab cov tshuaj tiv thaiv kab mob khi rau saum npoo ntawm cov kab mob los ntawm cov txheej txheem hu ua opsonisation cov kab mob Opsonised yog, yog li ntawd, coated nrog cov molecules uas phagocytic hlwb paub thiab teb rau.
Yuav ua li cas ntxiv cov kab ke tiv thaiv kab mob?
Complement ua haujlwm nrog lub cev tiv thaiv kab mob
Proteins ntawm ua kom lub cev muaj kev sib raug zoo nrog ib leeg los khi cov kab mob thiab ua rau cov kab mob inflammatory cascadetxhawm rau tiv thaiv kab mob. Ntau cov protein ntxiv yog cov proteases uas tau qhib los ntawm proteolytic cleavage.
Qhov cuam tshuam ntawm kev ua kom tiav yog dab tsi?
Nws ua kom tau txais peb qhov txiaj ntsig tseem ceeb rau cov kab mob microbes: cell lysis thaum sib dhos thiab tso rau ntawm lub davhlau ya nyob twg membrane nres complex (MAC), ntxiv kev kho kom haum xeeb, thiab tso tawm ntawm anaphylatoxins uas txhim kho qhov mob hauv zos..
