Acylation yog tshuaj lom neeg cov tshuaj tiv thaiv siv los ntxiv ib pawg acyl rau ib qho chaw Cov tshuaj tiv thaiv acylation feem ntau yog Friedel-Crafts acylation, muaj npe tom qab cov kws tshawb fawb uas tshawb pom nws. Cov txheej txheem uas ua rau cov tshuaj tiv thaiv no yog kev hloov pauv ntawm electrophilic aromatic.
Yuav ua li cas acylation tshuaj tiv thaiv piv txwv?
Acylation: Ib qho tshuaj tiv thaiv uas ib pawg acyl ntxiv rau hauv molecule. Hauv qhov piv txwv no ntawm Friedel-Crafts acylation cov tshuaj tiv thaiv, benzene yog acylated nrog acetyl chloride nyob rau hauv lub xub ntiag ntawm AlCl 3(ib Lewis acid catalyst) rau tsim acetophenone. Cov tshuaj tiv thaiv ua raws li electrophilic aromatic hloov mechanism.
Qhov twg hauv qab no yuav tsis muab tshuaj tiv thaiv acylation?
Nitrobenzene tsis raug Friedel-Crafts cov tshuaj tiv thaiv, vim hais tias pawg nitro hauv nitrobenzene yog ib pawg muaj zog tshem tawm thiab pab pawg no tawm tsam electrophile los ntawm nws. … Li no, nitrobenzene yuav tsis raug Friedel-Crafts tshuaj tiv thaiv yooj yim.
Yuav ua li cas acylation tshwm sim?
Tus tawm tsam ntawm cov ntxhiab tsw qab nrog cov kua qaub chloride (los yog acid anhydride) nyob rau hauv lub xub ntiag ntawm ib qho txhuas chloride catalyst yog siv los qhia ib pawg acyl (C=O) rau hauv lub nplhaib aromatic los ntawm Electrophilic aromatic hloov tshuab Cov tshuaj tiv thaiv zoo li no yog Friedel-Crafts acylation cov tshuaj tiv thaiv.
Ib co piv txwv ntawm tus neeg sawv cev acylating yog dab tsi?
Isocyanates yog lawv tus kheej acylating agents, ntawm ib hom uas kuj muaj xws li isothiocyanates (RN=C=S), ketenes (R2 C=C=O), thiab carbon dioxide (O=C=O). Lawv hnov mob ntau dua los yog tsawg dua nrog cov thawj thiab feem ntau cov amines tsim, feem, ureas, thioureas (RNHCSNHR), amides, thiab ntsev ntawm carbamic acid (RNHCO 2 - RNH3+).
