Cov tshuaj tiv thaiv kab mob ntawm cov tshuaj aspirin (acetylsalicylic acid) yog vim inhibition ntawm platelet muaj nuj nqi los ntawm acetylation ntawm platelet cyclooxygenase (COX) ntawm lub luag haujlwm tseem ceeb amino acid serine529.
Yuav ua li cas yog cov tshuaj aspirin ntawm platelet muaj nuj nqi?
Aspirin ua rau platelets los ntawm acetylates cyclooxygenase enzyme ntawm txoj hauj lwm serine 529, ua rau txo qis kev tsim ntawm cyclic endoperoxides (prostaglandin G2 thiab prostaglandin H2) thiab thromboxane los ntawm arachidonic acid.
Puas aspirin tiv thaiv platelet activation?
Nws zoo nkaus li tias kev tiv thaiv rau cov tshuaj aspirin tuaj yeem cuam tshuam nrog kev nce ntawm cov hlab ntsha thrombotic txawm tias muaj mob ntev. Hauv ex vivo kev soj ntsuam siv aggregometry, nrog sodium arachidonate li agonist, aspirin inhibits platelet aggregation irreversibly nyob rau hauv feem ntau neeg.
Puas aspirin ua rau cov ntshav qis?
Aspirin tsis muaj kev cuam tshuam hauv vitro ntawm cov platelet suav, ntim lossis loj.
Cov tshuaj dab tsi cuam tshuam rau platelet suav?
Lwm cov tshuaj uas ua rau cov tshuaj tiv thaiv thrombocytopenia suav nrog:
- YFurosemide.
- Kub, siv los kho mob caj dab.
- Nonsteroidal anti-inflammatory tshuaj (NSAIDs)
- Penicillin.
- YQuinidine.
- Quinine.
- YRanitidine.
- YSulfonamides.
Aspirin Aspirin
