Clonal deletion tuaj yeem tshwm sim hauv nruab nrab thaum lub sijhawm pib sib txawv ntawm cov tshuaj tiv thaiv tshwj xeeb T hlwb lossis B hlwb lossis txawm tias tom qab hauv cov chaw peripheral. Nyob rau hauv rooj plaub ntawm T hlwb, qhov chaw ntawm T cell sib txawv yog thymus (Sprent thiab Webb, 1995).
Dab tsi tshwm sim thaum lub sijhawm tshem tawm clonal?
Clonal deletion yog tshem tawm los ntawm apoptosis ntawm B hlwb thiab T hlwb uas tau nthuav tawm cov receptors rau nws tus kheej ua ntej txhim kho mus rau hauv cov tshuaj tiv thaiv kab mob siab tshaj plaws Qhov no tiv thaiv kev lees paub thiab kev puas tsuaj ntawm tus kheej lub hlwb, ua rau nws yog hom kev xaiv tsis zoo lossis qhov nruab nrab kam rau ua.
Vim li cas thiaj xaiv clonal tshwm sim?
Clonal xaiv yog txoj kev xav uas tshwj xeeb antigen receptors muaj nyob ntawm lymphocytes ua ntej lawv nthuav tawm nrog an antigen vim kev hloov pauv tsis sib xws thaum pib loj hlob thiab loj hlobTom qab kev nthuav qhia antigen, xaiv cov lymphocytes tau txais kev nthuav dav clonal vim lawv muaj qhov xav tau antigen receptor.
kev xaiv clonal tshwm sim nyob qhov twg?
Qhov kev ua kom muaj no tshwm sim hauv cov kab mob lymphoid thib ob xws li tus po thiab cov qog ntshav. Nyob rau hauv luv luv, txoj kev xav yog ib qho kev piav qhia ntawm lub mechanism rau tiam ntawm ntau haiv neeg ntawm antibody tshwj xeeb.
clonal expansion tshwm sim nyob qhov twg?
Koj tuaj yeem qhia tau tias kev nthuav dav clonal tshwm sim thaum koj xav tias pob khaus (cov qog o o) hauv koj lub caj dab lossis lwm qhov chaw. Thaum cov lymphocytes ntau thaum lub sij hawm clonal expansion, ib txhia ntawm lawv yog destined mus nyob raws li lub cim xeeb T thiab B hlwb.
