Daim duab 1. DNA methylation yog ib qho txheej txheem epigenetic ntawm chromatin remodeling uas regulates gene expression. Methylation ntawm cytosine residues los ntawm DNA methyltransferase represses transcription thiab switches noob tawm.
DNA methylation ua li cas rau chromatin?
DNA methylation inhibits gene qhia hauv cov tsiaj hlwb, tej zaum los ntawm kev cuam tshuam cov qauv chromatin. Cov kev tshawb fawb biochemical qhia tias cov txheej txheem no tuaj yeem kho los ntawm methyl-specific binding proteins uas nrhiav cov tshuab enzymatic muaj peev xwm hloov kho histone hauv zos.
Yuav ua li cas thaum DNA yog methylated?
DNA methylation yog txheej txheem lom neeg uas cov methyl pawg tau ntxiv rau DNA molecule. Methylation tuaj yeem hloov pauv cov haujlwm ntawm DNA ntu yam tsis hloov cov kab keThaum nyob hauv cov noob caj noob ces, DNA methylation feem ntau ua rau txo qis cov noob hloov pauv.
Puas yog methylated DNA qhib lossis kaw chromatin?
Cov kab sib txuas tshwj xeeb ntawm cov chaw acetylated thiab methylated yog txuam nrog " qhib" lossis "kaw" chromatin formations thiab tam sim no hu ua "histone code." Qhov "code" no cuam tshuam cov protein-protein kev sib cuam tshuam uas ua rau lub sijhawm luv thiab ntev ntawm kev hloov pauv thiab, ntxiv rau, tuaj yeem sawv cev …
Vim li cas DNA thiaj yuav tsum tau methylated?
DNA methylation yog qhov tseem ceeb rau kev ntsiag to cov ntsiab lus rov qab, tswj cov ntaub so ntswg tshwj xeeb ntawm cov noob qhia, genomic imprinting, thiab X chromosome inactivationTseem ceeb, DNA methylation nyob rau hauv ntau thaj tsam genomic tuaj yeem ua rau muaj kev cuam tshuam sib txawv. nyob rau hauv cov kev ua genetic raws li hauv qab genetic sequence.
