Kev txiav txim siab ntawm 5-methylcytosine ua rau thymine thiab ammonia. Qhov no yog ib qho kev hloov nucleotide ntau tshaj plaws.
Thaum cov methylated cytosine dhau mus deamination nws dhau los ua lus nug?
Yuav ua li cas thaum cytosine deaminated thiab nws kho li cas? Cytosine hloov mus rau Uracil Kho los ntawm BER.
Dab tsi ua rau cytosine deamination?
Cytosine deamination, zoo li AP qhov chaw tsim, yog tshwm sim by hydrolysis thiab tej zaum muaj nyob hauv DNA rho tawm los ntawm ntau qhov chaw. … Vim hais tias deamination ntawm cytosine yuav ua rau inhibition ntawm PCR los yog mutagenic DNA cov khoom, qhov no yog ib qho teeb meem tshwj xeeb tshaj yog nyob rau hauv txoj kev uas DNA ib theem zuj zus tseem ceeb heev.
Yuav ua li cas thaum lub sij hawm cytosine deamination thiab nws kho li cas?
Deamination hloov lub hauv paus cytosine rau hauv uracil Qhov no ua rau ob lub helix uas G hauv ib txoj hlua khi nrog U hauv lwm qhov. Lub U yog yav tas los C, tab sis tau hloov mus rau U los ntawm kev deamination. Cov uracil raug kuaj pom thiab tshem tawm, tawm hauv lub hauv paus-tsawg nucleotide.
Dab tsi yog cov khoom ntawm deamination ntawm cytosine thiab 5 methyl cytosine raws li?
Ntawm cov kev tshwm sim no muaj ob peb yam uas yuav ua rau muaj kev hloov pauv hloov pauv, tshwj xeeb tshaj yog hydrolytic deamination ntawm cytosine thiab 5-methylcytosine, uas ua rau uracil thiab thymine, feem.
