Hauv daim siab hlwb, nws yog GLUT2 uas tau qhia thiab GLUT4 yog qhia nyob rau theem tseem ceeb hauv cov ntaub so ntswg-sensitive insulin (cov leeg hlwb, lub plawv hlwb, adipoyctes).
YPuas GLUT4 qhia hauv daim siab hlwb?
Kev piav qhia, GLUT 4 qhia nyob rau hauv cov xwm txheej hyperglycemic pom tias muaj zog dua nyob rau hauv tag nrho cov kabmob lossis cov ntaub so ntswg piv rau cov xwm txheej ib txwm muaj (Daim duab 4). Hauv daim siab, GLUT4 yog nthuav tawm hauv cov cell nucleus, cytoplasm, thiab plasma membrane.
GLUT4 nyob qhov twg?
GLUT4 (SLC2A4) yog cov tshuaj insulin teb cov piam thaj, pom muaj feem ntau hauv cov leeg nqaij thiab adipocytes (fat cells) Tom qab noj mov, qabzib uas tau nqus los ntawm lub plab zom mov. thiab circulates hauv cov ntshav tam sim no txhawb kev tso tawm ntawm cov tshuaj insulin los ntawm cov txiav (Daim duab 4.10).
Vim li cas lub siab thiaj muaj GLUT2?
GLUT2 yog cov piam thaj loj thauj mus rau hauvβ -cells ntawm pancreatic islets thiab hepatocytes. … Hauv β-hlwb, tus nqi ntawm cov piam thaj metabolism tswj cov tshuaj insulin secretion, tab sis hauv daim siab, glucose metabolism thiab thauj yog qhov tseem ceeb rau glycogen synthesis tom qab thiab gluconeogenesis (1–6).
Puas GLUT 1 hauv siab?
Txawm hais tias GLUT2 yog cov piam thaj loj thauj khoom ntawm hepatocytes, qhov uas nws koom nrog hauv cov piam thaj nce thiab tso tawm hauv lub xeev pub thiab yoo mov, raws li (Thorens li al., 1990; Mueckler thiab Thorens, 2013), GLUT1 kuj tseem muaj nyob hauv daim siab (Karim li al., 2012), qhov uas nws tau sau thiab qhia los ntawm ob qho tib si …
