Lub cev tib neeg lub cev ua rau cov laus lossis cov hlwb puas tas li, kom cov hlwb tshiab tuaj yeem ua lawv qhov chaw. Cov txheej txheem ntuj tsim ntawm cellular self-destruction (hu ua "apoptosis" los ntawm ib lo lus Greek thaum ub lub ntsiab lus "poob") yog hard-wired rau hauv hlwb.
Lub xovtooj tua nws tus kheej li cas?
Yog cov hlwb tsis xav tau ntxiv lawm, lawv ua rau kev tua tus kheej los ntawm kev ua kom lub cev tuag. Cov txheej txheem no yog vim li no hu ua programmed cell tuag, txawm hais tias nws feem ntau hu ua apoptosis (los ntawm lo lus Greek txhais tias "poob tawm," raws li nplooj ntawm tsob ntoo).
Vim li cas apoptosis tshwm sim?
Apoptosis tshwm sim ib txwm thaum lub sijhawm kev loj hlob thiab kev laus thiab ua lub tshuab homeostatic tswj cov cell hauv cov ntaub so ntswg. Apoptosis kuj tshwm sim raws li kev tiv thaiv kev tiv thaiv xws li hauv kev tiv thaiv kab mob lossis thaum lub hlwb puas los ntawm cov kab mob lossis cov kab mob tsis zoo (Norbury thiab Hickson, 2001).
Yuav ua li cas thaum lub xov tooj ntawm tes puas lawm?
Apoptosis, qee zaum hu ua "kev tua tus kheej ntawm tes," yog ib txwm ua, txheej txheem ntawm kev rhuav tshem cellular. Txawm hais tias nws cuam tshuam txog kev tuag ntawm tes, apoptosis ua haujlwm zoo thiab tiv thaiv peb lub cev. … Thaum lub sij hawm apoptosis, lub xovtooj ntawm tes qis thiab rub tawm ntawm nws cov neeg nyob ze
Koj ua li cas thiaj ua rau apoptosis?
Induction ntawm apoptosis los ntawm kev noj zaub mov chemopreventive agents. Txoj kev extrinsic yog pib los ntawm ligation ntawm transmembrane tuag receptors (CD95, TNF receptor thiab TRAIL receptor) kom qhib cov membrane-proximal (activator) caspase- 8 ntawm adapter molecule FADD. Qhov no nyob rau hauv lem cleaves thiab activates effector caspase-3.
