Fibroblast kev loj hlob zoo tshaj plaws receptors (FGFRs) yog tsev neeg ntawm tyrosine kinases qhia ntawm cov cell membrane uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab cov neeg laus.
Qhov kev loj hlob receptor nyob qhov twg?
Growth factor receptors muaj nyob hauv the plasma membrane of so cells as monomers or (pre)dimers. Ligand binding ua rau muaj kev txiav txim siab dua oligomerization ntawm ligand-receptor complexes.
Muaj pes tsawg FGF receptors muaj?
Cov tsev neeg fibroblast kev loj hlob zoo receptor (FGFR) muaj xws li plaub receptors uas khi 18 ligands hu ua fibroblast kev loj hlob yam, siv heparin ua tus co-factor 1 , 2, 3, 4.
FGFR nyob qhov twg?
Lub noob FGFR1 nyob ntawm tib neeg chromosome 8 ntawm txoj hauj lwm p11. 23 (piv txwv li 8p11. 23), muaj 24 exons, thiab cov lej rau Precursor mRNA uas hloov pauv ntawm exons 8A lossis 8B yog li tsim ob mRNAs coding rau ob FGFR1 isoforms, FGFR1-IIIb (tseem hu ua FGFR1b) thiab FGFR1-IIIc (tseem hu ua FGFR1c), feem.
Dab tsi receptors ua qhov kev loj hlob cuam tshuam rau?
Txoj Kev Loj Hlob (tseem hu ua trophic yam) khi rau cell-nto receptors txhawm rau pib txoj kev taw qhia uas ua rau muaj kev loj hlob thiab sib txawv ntawm ntau hom cell sib txawv.
