Qhov kev ua haujlwm hauv vitro kev soj ntsuam kev ntxub ntxaug ntawm cov kab mob CDH1 tsis muaj kev hloov pauv (ua rau cov cell adhesion thiab ua rau muaj kev cuam tshuam) thiab cov uas tsis cuam tshuam rau phenotype.
Kev hloov pauv dab tsi cuam tshuam rau phenotype?
Recessive mutations ua rau kev poob haujlwm, uas yog npog yog tias muaj daim qauv ntawm cov noob. Rau qhov mutant phenotype tshwm sim, ob qho tib si alleles yuav tsum nqa qhov kev hloov pauv. Cov kev hloov pauv tseem ceeb ua rau muaj kev hloov pauv phenotype nyob rau hauv lub xub ntiag ntawm ib txwm luam ntawm cov noob.
Dab tsi yog qhov cuam tshuam ntawm kev hloov pauv tsis raug?
Missense mutations tuaj yeem cuam tshuam DNA-transcription yam uas ua rau hloov pauv cov lus qhia ntawm cov protein sib xws Hloov cov tsiaj qus-hom protein qhia nyob rau hauv qhov chaw uas nws tsim los ua haujlwm yuav cuam tshuam lub voj voog ntawm tes thiab ua rau muaj kab mob [20].
Kev hloov pauv dab tsi tsis cuam tshuam rau phenotype?
Silent mutations yog kev hloov pauv hauv DNA uas tsis muaj kev cuam tshuam rau lub cev phenotype. Lawv yog ib hom kev hloov pauv nruab nrab.
Kev hloov pauv ntawm tes puas cuam tshuam rau phenotype?
Tsuas yog kev hloov pauv uas tseem ceeb rau kev hloov pauv loj yog cov uas tuaj yeem kis mus rau cov xeeb ntxwv. Cov no tshwm sim hauv cov qe menyuam yaus xws li qe thiab phev thiab hu ua kab kab hloov pauv. Tsis muaj kev hloov pauv tshwm sim hauv phenotype Qee qhov kev hloov pauv tsis muaj qhov cuam tshuam rau cov phenotype ntawm cov kab mob.
