Glycans ua haujlwm ntau yam ntawm cov qauv thiab kev ua haujlwm hauv daim nyias nyias thiab zais cov proteins. Feem ntau ntawm cov proteins ua ke nyob rau hauv qhov ntxhib endoplasmic reticulum underglycosylation. Glycosylation kuj tseem muaj nyob hauv cytoplasmthiab nucleus raws li kev hloov kho O-GlcNAc.
Glycosylated proteins pom nyob qhov twg?
Glycosylation ntawm cov protein thiab lipids tshwm sim hauv cov endoplasmic reticulum (ER) thiab Golgi apparatus, nrog rau feem ntau ntawm cov davhlau ya nyob twg tshwm sim hauv cis-, medial- thiab trans-Golgi. compartments.
Puas muaj glycosylated proteins hauv cytosol?
duab 17.1. Muaj peev xwm mechanisms rau glycosylation ntawm cytoplasmic proteins. (a) Hauv cov qauv yooj yim tshaj plaws, glycosyltransferases muaj nyob hauv cytoplasmthiab hloov cov suab thaj los ntawm nucleotide qab zib pub rau cov neeg txais cov protein hauv cytoplasm.
Cov proteins ua ntej glycosylated nyob qhov twg?
N-txuas protein glycosylation pib nrog cov synthesis ntawm oligosaccharide precursor nyob rau hauv lub cytoplasmic, uas yog ces translocated mus rau endoplasmic reticulum (ER) lumen. Tom qab oligosaccharide precursor tau dhau los ua ntau qhov kev hloov kho, nws raug xa mus rau asparagine residue ntawm nascent protein.
% ntawm cov proteins twg yog glycosylated?
Glycosylation yog ib qho ntawm cov kev hloov pauv hloov pauv ntau tshaj plaws (PTMs) ntawm cov protein. Tsawg kawg 50% ntawm tib neeg cov proteins yog glycosylated nrog qee qhov kev kwv yees siab li 70%. Kev tsom xam glycoprotein yuav tsum tau txiav txim siab ob qhov chaw ntawm glycosylation nrog rau cov qauv glycan cuam tshuam nrog txhua qhov chaw.
